MMPX

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Cat.No. 0552 - MMPX | C12H18N4O3 | CAS No. 78033-08-6
Description: PDE1 inhibitor
Chemical Name: 8-Methoxymethyl-3-isobutyl-1-methylxanthine
Datasheet
Citations
Literature

Biological Activity

Specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM).

Technical Data

M. Wt 266.3
Formula C12H18N4O3
Storage Store at RT
CAS Number 78033-08-6
PubChem ID 155806
InChI Key NBLBCGUCPBXKOV-UHFFFAOYSA-N
Smiles COCC1=NC2=C(N1)N(CC(C)C)C(=O)N(C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 266.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.76 mL 18.78 mL 37.55 mL
5 mM 0.75 mL 3.76 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.76 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wells and Mille (1988) Methylxanthine inhibitors of phosphodiesterases. Methods Enzymol. 159 489 PMID: 2457788


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Keywords: MMPX, supplier, PDE1, inhibitors, inhibits, calmodulin-sensitive, cyclic, GMP, phosphodiesterases, Phosphodiesterases, Tocris Bioscience

Citations for MMPX

Citations are publications that use Tocris products.

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for MMPX

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