MMK 1

Discontinued Product

MMK 1 (Cat. No. 3537) has been withdrawn from sale for commercial reasons.
Description: Potent and selective FPR2 agonist
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews (1)

Biological Activity for MMK 1

MMK 1 is a potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.

DMSO is not recommended as a solvent for this peptide.

Technical Data for MMK 1

M. Wt 1610.97
Formula C75H123N19O18S
Sequence LESIFRSLLFRVM
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 271246-66-3
PubChem ID 25074458
InChI Key PWBQRCXCXXGUGY-AJOXZCOLSA-N
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MMK 1

Certificate of Analysis / Product Datasheet
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References for MMK 1

References are publications that support the biological activity of the product.

Hu et al (2001) Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J.Leukoc.Biol. 70 155 PMID: 11435499

Klein et al (1998) Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nature Biotech. 16 1334

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Keywords: MMK 1, MMK 1 supplier, Potent, selective, FPR2, agonists, FPRL, Formyl, Peptide, Receptors, MMK1, 3537, Tocris Bioscience

2 Citations for MMK 1

Citations are publications that use Tocris products. Selected citations for MMK 1 include:

Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888


Reviews for MMK 1

Average Rating: 4 (Based on 1 Review.)

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Following protocol.
By Christopher Durrant on 01/09/2020
Assay Type: Ex Vivo
Species: Human

looking at human formyl peptide receptor

Followed publication