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Cat.No. 3537 - MMK 1 | Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met | CAS No. 271246-66-3
Description: Potent and selective FPR2 agonist
Citations (1)

Biological Activity

Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.

Technical Data

M. Wt 1610.97
Formula C75H123N19O18S
Storage Store at -20°C
CAS Number 271246-66-3
PubChem ID 25074458
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 25% ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1610.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.1 mL 6.21 mL
5 mM 0.12 mL 0.62 mL 1.24 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Hu et al (2001) Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J.Leukoc.Biol. 70 155 PMID: 11435499

Karlsson et al (2009) The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels. Cell Calcium 45 431 PMID: 19282028

Klein et al (1998) Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nature Biotech. 16 1334 PMID:

If you know of a relevant reference for MMK 1, please let us know.

View Related Products by Target

Keywords: Potent selective FPR2 agonists FPRL Formyl Peptide Receptors MMK1 Formyl Peptide Receptor Peptide

1 Citation for MMK 1

Citations are publications that use Tocris products. Selected citations for MMK 1 include:

Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962

Do you know of a great paper that uses MMK 1 from Tocris? If so please let us know.

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