MM 77 dihydrochloride

Pricing Availability   Qty
Cat.No. 0933 - MM 77 dihydrochloride | C19H27N3O3.2HCl | CAS No. 159187-70-9
Description: 5-HT1A (postsynaptic) antagonist
Chemical Name: 1-(2-Methoxyphenyl)-4-(4-succinimidobutyl)piperazine dihydrochloride
Literature (5)

Biological Activity for MM 77 dihydrochloride

MM 77 dihydrochloride is a highly potent and fairly selective 5-HT1A ligand, which may be a full antagonist at postsynaptic receptors.

Technical Data for MM 77 dihydrochloride

M. Wt 418.36
Formula C19H27N3O3.2HCl
Storage Store at RT
CAS Number 159187-70-9
PubChem ID 45073441

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MM 77 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.38 75

Preparing Stock Solutions for MM 77 dihydrochloride

The following data is based on the product molecular weight 418.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.19 mL 15.94 mL 31.87 mL
3.75 mM 0.64 mL 3.19 mL 6.37 mL
7.5 mM 0.32 mL 1.59 mL 3.19 mL
37.5 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for MM 77 dihydrochloride

References for MM 77 dihydrochloride

References are publications that support the biological activity of the product.

Mokrosz et al (1994) 1-(2-Methoxyphenyl)-4-(4-succinimidobutyl)piperazine (MM 77): a new, potent, postsynaptic antagonist of 5-HT1A receptors. Med.Chem.Res. 4 161

If you know of a relevant reference for MM 77 dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT1A Receptor Antagonists

Keywords: MM 77 dihydrochloride, MM 77 dihydrochloride supplier, 5-HT1A, postsynaptic, antagonists, Serotonin, Receptors, MM77, dihydrochloride, 0933, Tocris Bioscience

Citations for MM 77 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for MM 77 dihydrochloride. Do you know of a great paper that uses MM 77 dihydrochloride from Tocris? Please let us know.

Reviews for MM 77 dihydrochloride

There are currently no reviews for this product. Be the first to review MM 77 dihydrochloride and earn rewards!

Have you used MM 77 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.


Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.