MM 07

Pricing Availability   Qty
Cat.No. 7053 - MM 07 | Cys-Arg-Pro-Arg-Leu-Cys-His-Lys-Gly-Pro-Met-Pro-Phe (Modification: Disulfide bridge: 1-6) | CAS No. 1876450-21-3
Description: Apelin receptor biased agonist; exhibits bias for the G protein pathway
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.

Technical Data

M. Wt 1539.89
Formula C67H106N22O14S3
Sequence CRPRLCHKGPMPF

(Modification: Disulfide bridge: 1-6)

Storage Store at -20°C
CAS Number 1876450-21-3
PubChem ID 134828250
InChI Key RKFGCZWTURNFPN-SVENNQHVSA-N
Smiles O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@H](CCSC)NC([C@H](CCC3)N3C(CNC([C@H](CCCCN)NC([C@@H](NC([C@H](CSSC[C@@H](C(N[C@@]4([H])CCCNC(N)=N)=O)N)NC([C@](NC([C@@H](NC([C@@](CCC5)([H])N5C4=O)=O)CCCNC(N)=N)=O)([H])CC(C)C)=O)=O)CC6=CN=CN6)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

Brame et al (2015) Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension 65 834 PMID: 25712721

Yang et al (2019) A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. Br.J.Pharmacol. 176 1206 PMID: 30710493


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Keywords: MM 07, MM 07 supplier, MM07, apelin, receptor, biased, agonists, agonism, G, protein, pathway, positive, inotropic, pulmonary, arterial, hypertension, PAH, Apelin, Receptors, 7053, Tocris Bioscience

Citations for MM 07

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Literature in this Area

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