MM 07

Discontinued Product

MM 07 (Cat. No. 7053) has been withdrawn from sale for commercial reasons.
Description: Apelin receptor biased agonist; exhibits bias for the G protein pathway
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for MM 07

MM 07 is an apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.

Technical Data for MM 07

M. Wt 1539.89
Formula C67H106N22O14S3
Sequence CRPRLCHKGPMPF

(Modification: Disulfide bridge: 1-6)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1876450-21-3
PubChem ID 134828250
InChI Key RKFGCZWTURNFPN-SVENNQHVSA-N
Smiles O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@H](CCSC)NC([C@H](CCC3)N3C(CNC([C@H](CCCCN)NC([C@@H](NC([C@H](CSSC[C@@H](C(N[C@@]4([H])CCCNC(N)=N)=O)N)NC([C@](NC([C@@H](NC([C@@](CCC5)([H])N5C4=O)=O)CCCNC(N)=N)=O)([H])CC(C)C)=O)=O)CC6=CN=CN6)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MM 07

Certificate of Analysis / Product Datasheet
Select another batch:

References for MM 07

References are publications that support the biological activity of the product.

Brame et al (2015) Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension 65 834 PMID: 25712721

Yang et al (2019) A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. Br.J.Pharmacol. 176 1206 PMID: 30710493

View Related Products by Product Action

View all Apelin Receptor Agonists

Keywords: MM 07, MM 07 supplier, MM07, apelin, receptor, biased, agonists, agonism, G, protein, pathway, positive, inotropic, pulmonary, arterial, hypertension, PAH, Apelin, Receptors, 7053, Tocris Bioscience

Citations for MM 07

Citations are publications that use Tocris products.

Currently there are no citations for MM 07.

Reviews for MM 07

There are currently no reviews for this product. Be the first to review MM 07 and earn rewards!

Have you used MM 07?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.