MLN 4760

Pricing Availability   Qty
Description: Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
Chemical Name: N-[(1S)-1-Carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
Purity: ≥98% (HPLC)

Biological Activity for MLN 4760

MLN 4760 is a highly potent, cell-permeable and selective inhibitor of angiotensin converting enzyme 2 (ACE2) (IC50 = 0.44 nM). MLN 4760 inhibits production of angiotensin (1-7) from angiotensin II and reduces ACE2 expression and activity in an animal model of lung inflammation.

Technical Data for MLN 4760

M. Wt 428.31
Formula C19H23Cl2N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 305335-31-3
PubChem ID 448281
Smiles ClC1=CC(CN2C(C[C@H](N[C@@H](CC(C)C)C(O)=O)C(O)=O)=CN=C2)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MLN 4760

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.83 100

Preparing Stock Solutions for MLN 4760

The following data is based on the product molecular weight 428.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.67 mL 23.35 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for MLN 4760

References are publications that support the biological activity of the product.

Mores et al (2008) Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J.Med.Chem. 51 2216 PMID: 18324760

Sodhi et al (2019) A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to Pseudomonas aeruginosa lung infection in mice. J.Immunol. 203 3000 PMID: 31645418

If you know of a relevant reference for MLN 4760, please let us know.

View Related Products by Target

View Related Products by Product Action

View all ACE2 Inhibitors

Keywords: MLN 4760, MLN 4760 supplier, MLN4760, C-16, C16, angiotensin, converting, enzyme, ACE2, selective, potent, inhibitors, inhibition, carboxypeptidase, 3345, Tocris Bioscience

Citations for MLN 4760

Citations are publications that use Tocris products.

Currently there are no citations for MLN 4760. Do you know of a great paper that uses MLN 4760 from Tocris? Please let us know.

Reviews for MLN 4760

There are currently no reviews for this product. Be the first to review MLN 4760 and earn rewards!

Have you used MLN 4760?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review