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Biological Activity for MLN 4760
MLN 4760 is a highly potent, cell-permeable and selective inhibitor of angiotensin converting enzyme 2 (ACE2) (IC50 = 0.44 nM). MLN 4760 inhibits production of angiotensin (1-7) from angiotensin II and reduces ACE2 expression and activity in an animal model of lung inflammation.
Technical Data for MLN 4760
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MLN 4760
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MLN 4760
The following data is based on the product molecular weight 428.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.33 mL||11.67 mL||23.35 mL|
|5 mM||0.47 mL||2.33 mL||4.67 mL|
|10 mM||0.23 mL||1.17 mL||2.33 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References for MLN 4760
References are publications that support the biological activity of the product.
Mores et al (2008) Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J.Med.Chem. 51 2216 PMID: 18324760
Sodhi et al (2019) A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to Pseudomonas aeruginosa lung infection in mice. J.Immunol. 203 3000 PMID: 31645418
If you know of a relevant reference for MLN 4760, please let us know.
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Keywords: MLN 4760, MLN 4760 supplier, MLN4760, C-16, C16, angiotensin, converting, enzyme, ACE2, selective, potent, inhibitors, inhibition, carboxypeptidase, 3345, Tocris Bioscience
Citations for MLN 4760
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