ML 299

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Description: Potent inhibitor of PLD1 and PLD2; CNS penetrant
Chemical Name: 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide
Purity: ≥98% (HPLC)

Biological Activity for ML 299

ML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.

Technical Data for ML 299

M. Wt 489.39
Formula C23H26BrFN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1426916-00-8
PubChem ID 56593054
Smiles O=C(N[C@@H](C)CN1CCC2(C(NCN2C3=CC(F)=CC=C3)=O)CC1)C4=CC=C(Br)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 299

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.94 100

Preparing Stock Solutions for ML 299

The following data is based on the product molecular weight 489.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for ML 299

References are publications that support the biological activity of the product.

O'Reilly et al (2013) Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695 PMID: 23445448

If you know of a relevant reference for ML 299, please let us know.

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Citations for ML 299

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