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ML 299 New
Biological Activity for ML 299
ML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.
Technical Data for ML 299
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 299
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ML 299
The following data is based on the product molecular weight 489.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.04 mL||10.22 mL||20.43 mL|
|5 mM||0.41 mL||2.04 mL||4.09 mL|
|10 mM||0.2 mL||1.02 mL||2.04 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References for ML 299
References are publications that support the biological activity of the product.
O'Reilly et al (2013) Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695 PMID: 23445448
If you know of a relevant reference for ML 299, please let us know.
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Citations for ML 299
Citations are publications that use Tocris products.
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Literature in this Area
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