ML 298 hydrochloride

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Cat.No. 4895 - ML 298 hydrochloride | C22H23F3N4O2.HCl
Description: Selective PLD2 inhibitor
Chemical Name: 3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]benzamide hydrochloride
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.

Compound Libraries

ML 298 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 468.9
Formula C22H23F3N4O2.HCl
Storage Desiccate at RT
PubChem ID 78243721
InChI Key GMGMJMDCWRCPHP-UHFFFAOYSA-N
Smiles O=C(NCCN2CCC(C(NCN3C4=CC(F)=CC=C4)=O)3CC2)C1=CC=C(F)C(F)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.72 25

Preparing Stock Solutions

The following data is based on the product molecular weight 468.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.66 mL 21.33 mL
5 mM 0.43 mL 2.13 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

O'Reilly et al (2013) Development of dual PLD1/2 adn PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695 PMID: 23445448


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Keywords: ML298 hydrochloride PLD2 phospholipase 2 inhibitors inhibits selective Phospholipases

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