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ML 298 hydrochloride
Selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 468.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||8.53 mL||42.65 mL||85.31 mL|
|1.25 mM||1.71 mL||8.53 mL||17.06 mL|
|2.5 mM||0.85 mL||4.27 mL||8.53 mL|
|12.5 mM||0.17 mL||0.85 mL||1.71 mL|
References are publications that support the biological activity of the product.
O'Reilly et al (2013) Development of dual PLD1/2 adn PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695 PMID: 23445448
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1 Citation for ML 298 hydrochloride
Citations are publications that use Tocris products. Selected citations for ML 298 hydrochloride include:
Hartlerode et al (2015) Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol 22 736 PMID: 26280532
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Literature in this Area
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