You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
ML 298 hydrochloride
Biological Activity for ML 298 hydrochloride
ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.
Technical Data for ML 298 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 298 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ML 298 hydrochloride
The following data is based on the product molecular weight 468.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||8.53 mL||42.65 mL||85.31 mL|
|1.25 mM||1.71 mL||8.53 mL||17.06 mL|
|2.5 mM||0.85 mL||4.27 mL||8.53 mL|
|12.5 mM||0.17 mL||0.85 mL||1.71 mL|
Product Datasheets for ML 298 hydrochloride
References for ML 298 hydrochloride
References are publications that support the biological activity of the product.
O'Reilly et al (2013) Development of dual PLD1/2 adn PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695 PMID: 23445448
If you know of a relevant reference for ML 298 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: ML 298 hydrochloride, ML 298 hydrochloride supplier, ML298, hydrochloride, PLD2, phospholipase, 2, inhibitors, inhibits, selective, Phospholipases, 4895, Tocris Bioscience
1 Citation for ML 298 hydrochloride
Citations are publications that use Tocris products. Selected citations for ML 298 hydrochloride include:
Hartlerode et al (2015) Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol 22 736 PMID: 26280532
Do you know of a great paper that uses ML 298 hydrochloride from Tocris? Please let us know.
Reviews for ML 298 hydrochloride
There are currently no reviews for this product. Be the first to review ML 298 hydrochloride and earn rewards!
Have you used ML 298 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.