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ML 190 is a selective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 488.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.23 mL||51.17 mL||102.34 mL|
|1 mM||2.05 mL||10.23 mL||20.47 mL|
|2 mM||1.02 mL||5.12 mL||10.23 mL|
|10 mM||0.2 mL||1.02 mL||2.05 mL|
References are publications that support the biological activity of the product.
Frankowski et al (2012) Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 3 221 PMID: 22737280
Hedrick et al (2011) Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro PMID: 22091479
If you know of a relevant reference for ML 190, please let us know.
Keywords: ML 190, ML 190 supplier, ML190, selective, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP, Kappa, Opioid, 4866, Tocris Bioscience
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