ML 190

Pricing Availability   Qty
Description: Selective κ opioid receptor antagonist
Chemical Name: N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for ML 190

ML 190 is a selective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.

Technical Data for ML 190

M. Wt 488.58
Formula C27H32N6O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1355244-02-8
PubChem ID 44665680

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 190

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.77 20

Preparing Stock Solutions for ML 190

The following data is based on the product molecular weight 488.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.23 mL 51.17 mL 102.34 mL
1 mM 2.05 mL 10.23 mL 20.47 mL
2 mM 1.02 mL 5.12 mL 10.23 mL
10 mM 0.2 mL 1.02 mL 2.05 mL

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References for ML 190

References are publications that support the biological activity of the product.

Frankowski et al (2012) Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 3 221 PMID: 22737280

Hedrick et al (2011) Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro PMID: 22091479

If you know of a relevant reference for ML 190, please let us know.

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Citations for ML 190

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.