Mitoglitazone

Pricing Availability Delivery Time Qty
Cat.No. 5799 - Mitoglitazone | C19H18N2O4S | CAS No. 146062-49-9
Description: Insulin sensitizer; exhibits low binding affinity at PPARγ
Alternative Names: CAY 10415, MSDC 0160
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).

Technical Data

M. Wt 370.42
Formula C19H18N2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 146062-49-9
PubChem ID 10429242
InChI Key IRNJSRAGRIZIHD-UHFFFAOYSA-N
Smiles CCC1=CC=C(C(COC2=CC=C(C=C2)CC3SC(NC3=O)=O)=O)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.04 100
ethanol 7.41 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 370.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.5 mL 27 mL
5 mM 0.54 mL 2.7 mL 5.4 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422 PMID: 23513224

Chen et al (2012) Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537 PMID: 22621923

Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551 PMID: 23690925


If you know of a relevant reference for Mitoglitazone, please let us know.

Keywords: Antidiabetic neurodegeneration Alzheimer's Parkinson's diseases mTOT target thiazolidinones insulin resistance mitochondria metabolism pyruvate carriers MPC hyperglycemia CAY 10415 MSDC 0160 Insulin and insulin-like Receptors

Citations for Mitoglitazone

Citations are publications that use Tocris products.

Currently there are no citations for Mitoglitazone. Do you know of a great paper that uses Mitoglitazone from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Mitoglitazone

Insulin

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.

Protocols

TODO: Add Protocols