Discontinued Product

Mitoglitazone (Cat. No. 5799) has been withdrawn from sale for commercial reasons.
Description: Insulin sensitizer; exhibits low binding affinity at PPARγ
Alternative Names: CAY 10415,MSDC 0160
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity for Mitoglitazone

Mitoglitazone is an insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).

Technical Data for Mitoglitazone

M. Wt 370.42
Formula C19H18N2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 146062-49-9
PubChem ID 10429242
Smiles CCC1=CC=C(C(COC2=CC=C(C=C2)CC3SC(NC3=O)=O)=O)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Mitoglitazone

Certificate of Analysis / Product Datasheet
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References for Mitoglitazone

References are publications that support the biological activity of the product.

Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422 PMID: 23513224

Chen et al (2012) Ins resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537 PMID: 22621923

Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione Ins sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551 PMID: 23690925

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Citations for Mitoglitazone

Citations are publications that use Tocris products.

Currently there are no citations for Mitoglitazone.

Reviews for Mitoglitazone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Mitoglitazone

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.