Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 370.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.7 mL||13.5 mL||27 mL|
|5 mM||0.54 mL||2.7 mL||5.4 mL|
|10 mM||0.27 mL||1.35 mL||2.7 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the products' biological activity.
Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422 PMID: 23513224
Chen et al (2012) Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537 PMID: 22621923
Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551 PMID: 23690925
If you know of a relevant reference for Mitoglitazone, please let us know.
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Keywords: Mitoglitazone, supplier, Antidiabetic, neurodegeneration, Alzheimer's, Parkinson's, diseases, mTOT, target, thiazolidinones, insulin, resistance, mitochondria, metabolism, pyruvate, carriers, MPC, hyperglycemia, CAY, 10415, MSDC, 0160, Insulin, and, insulin-like, Receptors, Insulin, and, Insulin-like, Receptors, Insulin, and, insulin-like, Receptors, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.