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Biological Activity for Mito-HE
Mito-HE is a fluorescent probe for imaging superoxide in mitochondria of living cells. Selective for mitochondrial superoxides over other reactive oxygen and nitrogen species. Can be used to detect mitochondrial superoxide in Parkinson's and Alzheimer's disease in vitro models. Excitation/emission maxima λ ~ 510/580 nm.
It is recommended to prepare stock solutions in DMSO.
Optical Data for Mito-HE
|Extinction Coefficient (ε)||11700 M-1cm-1|
Technical Data for Mito-HE
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Mito-HE
References are publications that support the biological activity of the product.
Rhee et al (2020) Modeling secondary iron overload cardiomyopathy with human induced pluripotent stem cell-derived cardiomyocytes. Cell Rep. 32 107886 PMID: 32668256
Renaudin et al (2021) BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance. Cell Rep. 36 109478 PMID: 34348152
Mukhopadhyay et al (2007) Simple quantitative detection of mitochondrial superoxide production in live cells. Biochem.Biophys.Res.Commun. 358 203 PMID: 17475217
Mukhopadhyay et al (2007) Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat.Protoc. 2 2295 PMID: 17853886
Robinson et al (2006) Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc.Natl.Acad.Sci.U.S.A. 103 15038 PMID: 17015830
Chen et al (2020) Trilobatin protects against Aβ 25-35-induced hippocampal HT22 cells apoptosis through mediating ROS/p38/caspase 3-dependent pathway. Front.Pharmacol. 11 584 PMID: 32508629
Chung et al (2016) Parkin and PINK1 patient iPSC-derived midbrain dopamine neurons exhibit mitochondrial dysfunction and α-synuclein accumulation. Stem Cell Rep. 7 664 PMID: 27641647
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Citations for Mito-HE
Citations are publications that use Tocris products.
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Literature in this Area
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Fluorescent Probes and Dyes Research Product Guide
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