(-)-MK 801 maleate
Less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate (Cat. No. 0924).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||8.43||25mM with gentle warming|
|physiological saline||8.43||25mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.96 mL||14.82 mL||29.64 mL|
|5 mM||0.59 mL||2.96 mL||5.93 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Genovese and Lu (1991) Effects of MK-801 stereoisomers on schedule-controlled behavior in rats. Psychopharmacology. 105 477 PMID: 1771215
Thompson et al (1990) Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-Methyl-D-aspartate antagonists. J.Med.Chem. 33 789 PMID: 1688947
If you know of a relevant reference for (-)-MK 801 maleate, please let us know.
View Related Products by Product Action
Keywords: NMDA antagonists Glutamate Receptors N-Methyl-D-Aspartate iGlur Ionotropic (-)-MK801 maleate MK801 NMDA Receptors
2 Citations for (-)-MK 801 maleate
Citations are publications that use Tocris products. Selected citations for (-)-MK 801 maleate include:
Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Pharmacol Exp Ther 25 4288 PMID: 15858055
Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551 PMID: 15140926
Do you know of a great paper that uses (-)-MK 801 maleate from Tocris? If so please let us know.
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