Milrinone

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Cat.No. 1504 - Milrinone | C12H9N3O | CAS No. 78415-72-2
Description: PDE3 inhibitor
Chemical Name: 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent cAMP phosphodiesterase inhibitor (IC50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo. Also available as part of the Phosphodiesterase Inhibitor Tocriset™.

Technical Data

M. Wt 211.22
Formula C12H9N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 78415-72-2
PubChem ID 4197
InChI Key PZRHRDRVRGEVNW-UHFFFAOYSA-N
Smiles CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.73 mL 23.67 mL 47.34 mL
5 mM 0.95 mL 4.73 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.73 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Alousi et al (1983) Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 5 804 PMID: 6195468

Shahid et al (1991) The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 104 471 PMID: 1665737

Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608


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Keywords: Milrinone, supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

2 Citations for Milrinone

Citations are publications that use Tocris products. Selected citations for Milrinone include:

Roberts et al (2010) Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 116 4297 PMID: 20664056

├śrstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. Dent Res J (Isfahan) 10 e0115547 PMID: 25738589


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Cardiovascular

Cardiovascular Research Product Guide

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