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Potent cAMP phosphodiesterase inhibitor (IC50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo. Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.73 mL||23.67 mL||47.34 mL|
|5 mM||0.95 mL||4.73 mL||9.47 mL|
|10 mM||0.47 mL||2.37 mL||4.73 mL|
|50 mM||0.09 mL||0.47 mL||0.95 mL|
References are publications that support the biological activity of the product.
Alousi et al (1983) Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 5 804 PMID: 6195468
Shahid et al (1991) The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 104 471 PMID: 1665737
Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608
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Keywords: Milrinone, Milrinone supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, 1504, Tocris Bioscience
2 Citations for Milrinone
Citations are publications that use Tocris products. Selected citations for Milrinone include:
Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. Dent Res J (Isfahan) 10 e0115547 PMID: 25738589
Roberts et al (2010) Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 116 4297 PMID: 20664056
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