Miglitol

Pricing Availability Delivery Time Qty
Cat.No. 4985 - Miglitol | C8H17NO5 | CAS No. 72432-03-2
Description: α-glucosidase inhibitor
Alternative Names: Bay m1009
Chemical Name: (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.

Compound Libraries

Miglitol is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 207.22
Formula C8H17NO5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 72432-03-2
PubChem ID 441314
InChI Key IBAQFPQHRJAVAV-ULAWRXDQSA-N
Smiles OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 100
water 20.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 207.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.26 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Aoki et al (2012) Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 120 121 PMID: 23018899

Goda et al (2007) Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 98 702 PMID: 17537288

Sels et al (1999) Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1 149 PMID: 11249557


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Keywords: Miglitol, supplier, Baym1009, antidiabetic, alpha, a, α-glucosidase, inhibitors, inhibits, Bay, m1009, Glycosylases, Glycosylases, Tocris Bioscience

Citations for Miglitol

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Literature in this Area

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells