Discontinued Product

Miglitol (Cat. No. 4985) has been withdrawn from sale for commercial reasons.
Description: α-glucosidase inhibitor
Alternative Names: Bay m1009
Chemical Name: (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol
Purity: ≥98% (HPLC)

Biological Activity for Miglitol

Miglitol is an inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.

Compound Libraries for Miglitol

Miglitol is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Miglitol

M. Wt 207.22
Formula C8H17NO5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 72432-03-2
PubChem ID 441314
Smiles OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Miglitol

References are publications that support the biological activity of the product.

Aoki et al (2012) Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 120 121 PMID: 23018899

Goda et al (2007) Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-Ins-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 98 702 PMID: 17537288

Sels et al (1999) Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1 149 PMID: 11249557

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Keywords: Miglitol, Miglitol supplier, Baym1009, antidiabetic, alpha, a, α-glucosidase, inhibitors, inhibits, Bay, m1009, Glycosylases, 4985, Tocris Bioscience

Citations for Miglitol

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Currently there are no citations for Miglitol.

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