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Submit ReviewMiglitol
Description: α-glucosidase inhibitor
Alternative Names: Bay m1009
Chemical Name: (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol
Purity: ≥98% (HPLC)
Biological Activity for Miglitol
Miglitol is an inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.
Compound Libraries for Miglitol
Miglitol is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Miglitol
| M. Wt | 207.22 |
| Formula | C8H17NO5 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 72432-03-2 |
| PubChem ID | 441314 |
| InChI Key | IBAQFPQHRJAVAV-ULAWRXDQSA-N |
| Smiles | OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Miglitol
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.72 | 100 | |
| DMSO | 20.72 | 100 |
Preparing Stock Solutions for Miglitol
The following data is based on the product molecular weight 207.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.83 mL | 24.13 mL | 48.26 mL |
| 5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
| 10 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.97 mL |
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Product Datasheets for Miglitol
References for Miglitol
References are publications that support the biological activity of the product.
Aoki et al (2012) Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 120 121 PMID: 23018899
Goda et al (2007) Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-Ins-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 98 702 PMID: 17537288
Sels et al (1999) Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1 149 PMID: 11249557
If you know of a relevant reference for Miglitol, please let us know.
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Keywords: Miglitol, Miglitol supplier, Baym1009, antidiabetic, alpha, a, α-glucosidase, inhibitors, inhibits, Bay, m1009, Glycosylases, 4985, Tocris Bioscience
Citations for Miglitol
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