MI 2 dihydrochloride
Biological Activity
Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.
Technical Data
| M. Wt | 448.48 |
| Formula | C18H25N5S2.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 6436801 |
| InChI Key | OJCKRNPLOZHAOU-UGKRXNSESA-N |
| Smiles | CCCC2=CC1=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C1S2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.85 | 100 | |
| water | 22.42 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 448.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.15 mL | 22.3 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID: 22286128
If you know of a relevant reference for MI 2 dihydrochloride, please let us know.
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Keywords: MI 2 dihydrochloride, supplier, MI2, menin, MLL, mixed, lineage, leukemia, lysine, histone, methyltransferases, interaction, inhibitors, inhibits, Lysine, Methyltransferases, Tocris Bioscience
Citations for MI 2 dihydrochloride
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Literature in this Area
Cancer Research Product Guide
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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
