MI 2 dihydrochloride

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Cat.No. 4707 - MI 2 dihydrochloride
Description: Menin-MLL interaction inhibitor
Chemical Name: 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.

Technical Data

M. Wt 448.48
Formula C18H25N5S2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 6436801
InChI Key OJCKRNPLOZHAOU-UGKRXNSESA-N
Smiles CCCC2=CC1=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C1S2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.42 50
DMSO 44.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 448.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID: 22286128


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Keywords: MI 2 dihydrochloride, supplier, MI2, menin, MLL, mixed, lineage, leukemia, lysine, histone, methyltransferases, interaction, inhibitors, inhibits, Other, Lysine, Methyltransferases, Lysine, Methyltransferases, Other, Lysine, Methyltransferases, Tocris Bioscience

Citations for MI 2 dihydrochloride

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