MI 2 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4707 - MI 2 dihydrochloride
Description: Menin-MLL interaction inhibitor
Chemical Name: 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.

Technical Data

M. Wt 448.48
Formula C18H25N5S2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 6436801
InChI Key OJCKRNPLOZHAOU-UGKRXNSESA-N
Smiles CCCC2=CC1=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C1S2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.85 100
water 22.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 448.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID: 22286128


If you know of a relevant reference for MI 2 dihydrochloride, please let us know.

View Related Products by Target

Keywords: MI 2 dihydrochloride, supplier, MI2, menin, MLL, mixed, lineage, leukemia, lysine, histone, methyltransferases, interaction, inhibitors, inhibits, Lysine, Methyltransferases, Tocris Bioscience

Citations for MI 2 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for MI 2 dihydrochloride. Do you know of a great paper that uses MI 2 dihydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Pathways for MI 2 dihydrochloride

Protocols

TODO: Add Protocols