MI 2 dihydrochloride

Discontinued Product

MI 2 dihydrochloride (Cat. No. 4707) has been withdrawn from sale for commercial reasons.
Cat.No. 4707 - MI 2 dihydrochloride
Description: Menin-MLL interaction inhibitor
Chemical Name: 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for MI 2 dihydrochloride

Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.

Technical Data for MI 2 dihydrochloride

M. Wt 448.48
Formula C18H25N5S2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 6436801
InChI Key OJCKRNPLOZHAOU-UGKRXNSESA-N
Smiles CCCC2=CC1=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C1S2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MI 2 dihydrochloride

References for MI 2 dihydrochloride

References are publications that support the biological activity of the product.

Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID: 22286128

Phillips et al (2019) Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc.Natl.Acad.Sci.U.S.A. 116 7957 PMID: 30923116

Keywords: MI 2 dihydrochloride, MI 2 dihydrochloride supplier, MI2, menin, MLL, mixed, lineage, leukemia, lysine, histone, methyltransferases, interaction, inhibitors, inhibits, Other, Lysine, Methyltransferases, 4707, Tocris Bioscience

Citations for MI 2 dihydrochloride

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Currently there are no citations for MI 2 dihydrochloride.

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