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Submit ReviewMI 2 dihydrochloride
Discontinued Product
MI 2 dihydrochloride (Cat. No. 4707) has been withdrawn from sale for commercial reasons.
Description: Menin-MLL interaction inhibitor
Chemical Name: 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.
Technical Data
| M. Wt | 448.48 |
| Formula | C18H25N5S2.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 6436801 |
| InChI Key | OJCKRNPLOZHAOU-UGKRXNSESA-N |
| Smiles | CCCC2=CC1=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C1S2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID: 22286128
Phillips et al (2019) Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc.Natl.Acad.Sci.U.S.A. 116 7957 PMID: 30923116
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Keywords: MI 2 dihydrochloride, MI 2 dihydrochloride supplier, MI2, menin, MLL, mixed, lineage, leukemia, lysine, histone, methyltransferases, interaction, inhibitors, inhibits, Other, Lysine, Methyltransferases, 4707, Tocris Bioscience
Citations for MI 2 dihydrochloride
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Currently there are no citations for MI 2 dihydrochloride.
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