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MI 2 dihydrochloride
Discontinued ProductMI 2 dihydrochloride (Cat. No. 4707) has been withdrawn from sale for commercial reasons.
Biological Activity for MI 2 dihydrochloride
Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.
Technical Data for MI 2 dihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MI 2 dihydrochloride
References for MI 2 dihydrochloride
References are publications that support the biological activity of the product.
Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID: 22286128
Phillips et al (2019) Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc.Natl.Acad.Sci.U.S.A. 116 7957 PMID: 30923116
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Keywords: MI 2 dihydrochloride, MI 2 dihydrochloride supplier, MI2, menin, MLL, mixed, lineage, leukemia, lysine, histone, methyltransferases, interaction, inhibitors, inhibits, Other, Lysine, Methyltransferases, 4707, Tocris Bioscience
Citations for MI 2 dihydrochloride
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Currently there are no citations for MI 2 dihydrochloride.
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