Mevastatin

Pricing Availability   Qty
Description: HMG-CoA reductase inhibitor
Alternative Names: Compactin
Chemical Name: (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl butanoate
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (3)

Biological Activity for Mevastatin

Mevastatin is an inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo. Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data for Mevastatin

M. Wt 390.52
Formula C23H34O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 73573-88-3
PubChem ID 64715
InChI Key AJLFOPYRIVGYMJ-INTXDZFKSA-N
Smiles [H][C@@]12C(C=C[C@H](C)[C@@]([H])2CC[C@@]3([H])OC(C[C@]([H])(O)C3)=O)=CCC[C@@H]1OC([C@@H](C)CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mevastatin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 9.76 25 with gentle warming
DMSO 19.53 50 with gentle warming

Preparing Stock Solutions for Mevastatin

The following data is based on the product molecular weight 390.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.12 mL 25.61 mL 51.21 mL
2.5 mM 1.02 mL 5.12 mL 10.24 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
25 mM 0.1 mL 0.51 mL 1.02 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Mevastatin

References are publications that support the biological activity of the product.

Amin-Hanjani et al (2001) Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 32 980 PMID: 11283400

Cohen et al (1984) Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density lipoprotein-receptor activity in the human hepatoma cell line Hep G2. Biochem.J. 222 35 PMID: 6089762

Wachtershauser et al (2001) HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 22 1061 PMID: 11408350


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Keywords: Mevastatin, Mevastatin supplier, HMG-CoA, reductases, inhibitors, inhibits, statins, Compactin, Reductase, 1526, Tocris Bioscience

6 Citations for Mevastatin

Citations are publications that use Tocris products. Selected citations for Mevastatin include:

Leznicki et al (2018) Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J Cell Sci 131 PMID: 29685892

Brown and Price (2007) Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Vet Microbiol 120 328 PMID: 17157450

Song et al (2019) A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Sci Data 6 190016 PMID: 30778261

Kant et al (2019) Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell 24 363 PMID: 30686764


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Literature in this Area

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