Methimepip dihydrobromide

Discontinued Product

Methimepip dihydrobromide (Cat. No. 2947) has been withdrawn from sale for commercial reasons.
Description: Extremely selective H3 agonist
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)-1-methylpiperidine dihydrobromide
Literature (2)

Biological Activity for Methimepip dihydrobromide

Extremely selective histamine H3 receptor agonist (pKi values are 9.0, 5.7, < 5.0 and < 5.0 for hH3, hH4, hH1 and hH2 receptors respectively). Potently inhibits EFS-evoked contractions of guinea pig ileum (pD2 = 8.26).

Technical Data for Methimepip dihydrobromide

M. Wt 341.09
Formula C10H17N3.2HBr
Storage Desiccate at RT
CAS Number 817636-54-7
PubChem ID 11313836
Smiles CN1CCC(CC2=CNC=N2)CC1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Methimepip dihydrobromide

References for Methimepip dihydrobromide

References are publications that support the biological activity of the product.

Kitbunnadaj et al (2005) N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. J.Med.Chem. 48 2100 PMID: 15771452

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Keywords: Methimepip dihydrobromide, Methimepip dihydrobromide supplier, selective, H3, agonists, Receptors, Histamine, histaminergic, 2947, Tocris Bioscience

Citations for Methimepip dihydrobromide

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Currently there are no citations for Methimepip dihydrobromide.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.