Methimepip dihydrobromide

Discontinued Product

Unfortunately Methimepip dihydrobromide (Cat. No. 2947) has been withdrawn from sale for commercial reasons.
Cat.No. 2947 - Methimepip dihydrobromide | C10H17N3.2HBr | CAS No. 817636-54-7
Description: Extremely selective H3 agonist
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)-1-methylpiperidine dihydrobromide
Datasheet
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Literature

Biological Activity

Extremely selective histamine H3 receptor agonist (pKi values are 9.0, 5.7, < 5.0 and < 5.0 for hH3, hH4, hH1 and hH2 receptors respectively). Potently inhibits EFS-evoked contractions of guinea pig ileum (pD2 = 8.26).

Technical Data

M. Wt 341.09
Formula C10H17N3.2HBr
Storage Desiccate at RT
CAS Number 817636-54-7
PubChem ID 11313836
Smiles CN1CCC(CC2=CNC=N2)CC1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 341.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.66 mL 29.32 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.47 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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References

References are publications that support the products' biological activity.

Kitbunnadaj et al (2005) N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. J.Med.Chem. 48 2100 PMID: 15771452

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Keywords: selective H3 agonists Receptors Histamine histaminergic Histamine H3 Receptors

Citations for Methimepip dihydrobromide

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