Discontinued Product

Unfortunately Metaphit (Cat. No. 0568) has been withdrawn from sale for commercial reasons.
Cat.No. 0568 - Metaphit | C18H24N2S | CAS No. 96316-00-6
Description: Acylator of PCP and σ receptors
Chemical Name: 1-(1-(3-Isothiocyanato)phenyl)cyclohexylpiperidine

Biological Activity

Acylator of PCP and σ-receptors.

Technical Data

M. Wt 300.46
Formula C18H24N2S
Storage Desiccate at -20°C
CAS Number 96316-00-6
PubChem ID 114745

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 300.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.64 mL 33.28 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Contreras et al (1986) Metaphit, an acylating ligand for phencyclidine receptors: characterization of in vivo actions in the rat. J.Pharmacol.Exp.Ther. 238 1101 PMID: 3018219

Debler et al (1989) Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. Eur.J.Pharmacol. 165 155 PMID: 2548879

Rafferty et al (1985) A specific acylating agent for the [3H]-phencyclidine receptors in rat brain. FEBS Lett. 181 318 PMID: 2982662

Reith et al (1991) Effect of metaphit on dopaminergic neurotransmission in rat striatal slices: involvement of the dopamine transporter and voltage-dependent sodium channel. J.Pharmacol.Exp.Ther. 259 1188 PMID: 1662274

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Keywords: Metaphit, supplier, Acylator, PCP, σ, sigma, receptors, Sigma-Related, Sigma-Related, Tocris Bioscience

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