Mepyramine maleate

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Cat.No. 0660 - Mepyramine maleate | C17H23N3O.C4H4O4 | CAS No. 59-33-6
Description: Selective H1 inverse agonist
Alternative Names: Pyrilamine maleate
Chemical Name: 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate
Datasheet
Citations (1)
Literature

Biological Activity

Selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Technical Data

M. Wt 401.46
Formula C17H23N3O.C4H4O4
Storage Store at RT
CAS Number 59-33-6
PubChem ID 5284451
InChI Key JXYWFNAQESKDNC-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.COC1=CC=C(CN(CCN(C)C)C2=CC=CC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.15 100
water 40.15 100
phosphate buffered saline 40.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 401.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.45 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Carlos et al (2004) Mepyramine, a histamine H1 receptor inverse agonist, binds perferentially to a G protein-coupled form of the receptor and sequesters G protein. J.Biol.Chem. 279 34431 PMID: 15192105

Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Liu et al (1994) Does the [3H] mepyramine binding site represent the histamine H1 receptor? Re-examination of the histamine H2 receptor with quinine. J.Pharmacol.Exp.Ther. 268 959 PMID: 8114011


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Keywords: Mepyramine maleate, supplier, Selective, H1, inverse, agonists, Receptors, Histamine, histaminergic, Pyrilamine, maleate, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience

1 Citation for Mepyramine maleate

Citations are publications that use Tocris products. Selected citations for Mepyramine maleate include:

Brandt et al (2003) Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 112 1666 PMID: 14660743


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