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Cat.No. 3276 - Mephenytoin | C12H14N2O2 | CAS No. 50-12-4
Description: CYP2C19 substrate. Anticonvulsant
Chemical Name: (±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
Purity: ≥98% (HPLC)

Biological Activity for Mephenytoin

Mephenytoin is a CYP2C19 and CYP2B6 substrate. Anticonvulsant.

Technical Data for Mephenytoin

M. Wt 218.25
Formula C12H14N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 50-12-4
PubChem ID 4060
Smiles O=C1C(C2=CC=CC=C2)(CC)NC(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mephenytoin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.37 20

Preparing Stock Solutions for Mephenytoin

The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 22.91 mL 114.55 mL 229.1 mL
1 mM 4.58 mL 22.91 mL 45.82 mL
2 mM 2.29 mL 11.45 mL 22.91 mL
10 mM 0.46 mL 2.29 mL 4.58 mL

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References for Mephenytoin

References are publications that support the biological activity of the product.

Knabe and Wunn (1980) Racemic and optically active hydantoins from disubstituted cyanoacetic acids. Arch.Pharmacol. 313 53

Foti et al (2008) CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles. Drug Meta. Dispos. 36 523 PMID: 18048485

Tamminga et al (2001) Mephenytoin as a probe for CYP2C19 phenotyping: effect of sample storage, intra-individual reproducibility and occurrence of adverse events. Br.J.Clin.Pharmacol. 51 471 PMID: 11422005

If you know of a relevant reference for Mephenytoin, please let us know.

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Keywords: Mephenytoin, Mephenytoin supplier, CYP2C19, Anticonvulsant, Cytochrome, P450, 3276, Tocris Bioscience

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