Mephenytoin

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Cat.No. 3276 - Mephenytoin | C12H14N2O2 | CAS No. 50-12-4
Description: CYP2C19 substrate. Anticonvulsant
Chemical Name: (±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

CYP2C19 and CYP2B6 substrate. Anticonvulsant.

Technical Data

M. Wt 218.25
Formula C12H14N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 50-12-4
PubChem ID 4060
InChI Key GMHKMTDVRCWUDX-UHFFFAOYSA-N
Smiles O=C1C(C2=CC=CC=C2)(CC)NC(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.37 20

Preparing Stock Solutions

The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.82 mL
5 mM 0.92 mL 4.58 mL 9.16 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Knabe and Wunn (1980) Racemic and optically active hydantoins from disubstituted cyanoacetic acids. Arch.Pharmacol. 313 53 PMID:

Foti et al (2008) CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles. Drug Meta. Dispos. 36 523 PMID: 18048485

Tamminga et al (2001) Mephenytoin as a probe for CYP2C19 phenotyping: effect of sample storage, intra-individual reproducibility and occurrence of adverse events. Br.J.Clin.Pharmacol. 51 471 PMID: 11422005


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Keywords: Mephenytoin, supplier, CYP2C19, Anticonvulsant, Cytochrome, P450, Cytochrome, P450, Tocris Bioscience

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