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Biological Activity for Melphalan
Melphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).
Technical Data for Melphalan
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Melphalan
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Melphalan
The following data is based on the product molecular weight 305.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||16.38 mL||81.91 mL||163.83 mL|
|1 mM||3.28 mL||16.38 mL||32.77 mL|
|2 mM||1.64 mL||8.19 mL||16.38 mL|
|10 mM||0.33 mL||1.64 mL||3.28 mL|
References for Melphalan
References are publications that support the biological activity of the product.
Blumberg et al (1965) An alkylating agent for multiple myeloma: melp. JAMA. 191 547 PMID: 14239026
Merck Index 12 5872
Bauer and Povirk (1997) Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 25 1211 PMID: 9092631
Mougenot et al (2006) In vitro cytotoxic effect of melp. and pilot phase II study in hormone-refractory prostate cancer. Anticancer Res. 26 2197 PMID: 16821586
If you know of a relevant reference for Melphalan, please let us know.
Keywords: Melphalan, Melphalan supplier, antineoplastics, alkylating, DNA, agents, chemotherapeutics, cytotoxic, crosslinks, Other, Apoptosis, 4619, Tocris Bioscience
Citations for Melphalan
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