Melphalan

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Cat.No. 4619 - Melphalan | C13H18Cl2N2O2 | CAS No. 148-82-3
Description: DNA alkylating agent; cytotoxic and antineoplastic
Chemical Name: 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).

Technical Data

M. Wt 305.2
Formula C13H18Cl2N2O2
Storage Store at RT
Purity ≥95% (HPLC)
CAS Number 148-82-3
PubChem ID 460612
InChI Key SGDBTWWWUNNDEQ-LBPRGKRZSA-N
Smiles ClCCN(CCCl)C1=CC=C(C[C@H](N)C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 6.1 20
DMSO 6.1 20

Preparing Stock Solutions

The following data is based on the product molecular weight 305.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.77 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Blumberg et al (1965) An alkylating agent for multiple myeloma: melphalan. JAMA. 191 547 PMID: 14239026

Merck Index 12 5872 PMID:

Bauer and Povirk (1997) Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 25 1211 PMID: 9092631

Mougenot et al (2006) In vitro cytotoxic effect of melphalan and pilot phase II study in hormone-refractory prostate cancer. Anticancer Res. 26 2197 PMID: 16821586


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Keywords: Melphalan, supplier, antineoplastics, alkylating, DNA, agents, chemotherapeutics, cytotoxic, crosslinks, Other, Apoptosis, Other, Apoptosis, Tocris Bioscience

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Melphalan

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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