Melatonin

Pricing Availability Delivery Time Qty
Cat.No. 3550 - Melatonin | C13H16N2O2 | CAS No. 73-31-4
Description: Endogenous hormone; agonist at MT1 and MT2
Chemical Name: N-Acetyl-5-methoxytryptamine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.

Compound Libraries

Melatonin is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 232.28
Formula C13H16N2O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 73-31-4
PubChem ID 896
InChI Key DRLFMBDRBRZALE-UHFFFAOYSA-N
Smiles O=C(C)NCCC2=CNC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.61 50

Preparing Stock Solutions

The following data is based on the product molecular weight 232.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.31 mL 21.53 mL 43.05 mL
5 mM 0.86 mL 4.31 mL 8.61 mL
10 mM 0.43 mL 2.15 mL 4.31 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bubenik (2008) Thirty four years since the discovery of gastrointestinal melatonin. J.Physiol.Pharmacol. 59 33 PMID: 18812627

Fischer et al (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp.Dermatol. 17 713 PMID: 18643846

Cardinali et al (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int.J.Neurosci. 119 821 PMID: 19326288


If you know of a relevant reference for Melatonin, please let us know.

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Keywords: Melatonin, supplier, Endogenous, hormone, agonists, MT1, MT2, Receptors, Melatonin, circadian, rhythms, Melatonin, (MT), Receptors, Tocris Bioscience

2 Citations for Melatonin

Citations are publications that use Tocris products. Selected citations for Melatonin include:

Huang et al (2010) Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons. Nature 114 124 PMID: 19969594

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Toxicol Sci 20 1298 PMID: 24574803


Do you know of a great paper that uses Melatonin from Tocris? If so please let us know.

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Reviews

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for Melatonin

Protocols

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