Pricing Availability   Qty
Description: Endogenous hormone; agonist at MT1 and MT2
Chemical Name: N-Acetyl-5-methoxytryptamine
Purity: ≥99% (HPLC)
Citations (10)
Reviews (1)

Biological Activity for Melatonin

Melatonin is an endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.

Compound Libraries for Melatonin

Melatonin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Melatonin

M. Wt 232.28
Formula C13H16N2O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 73-31-4
PubChem ID 896
Smiles O=C(C)NCCC2=CNC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Melatonin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.61 50

Preparing Stock Solutions for Melatonin

The following data is based on the product molecular weight 232.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.61 mL 43.05 mL 86.1 mL
2.5 mM 1.72 mL 8.61 mL 17.22 mL
5 mM 0.86 mL 4.31 mL 8.61 mL
25 mM 0.17 mL 0.86 mL 1.72 mL

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References for Melatonin

References are publications that support the biological activity of the product.

Bubenik (2008) Thirty four years since the discovery of gastrointestinal melatonin. J.Physiol.Pharmacol. 59 33 PMID: 18812627

Fischer et al (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp.Dermatol. 17 713 PMID: 18643846

Cardinali et al (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int.J.Neurosci. 119 821 PMID: 19326288

If you know of a relevant reference for Melatonin, please let us know.

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Keywords: Melatonin, Melatonin supplier, Endogenous, hormone, agonists, MT1, MT2, Receptors, Melatonin, circadian, rhythms, (MT), 3550, Tocris Bioscience

10 Citations for Melatonin

Citations are publications that use Tocris products. Selected citations for Melatonin include:

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Toxicol Sci 20 1298 PMID: 24574803

Costa et al (2015) The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice. Neurotoxicology 48 68 PMID: 25797475

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888

Huang et al (2010) Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons. Nature 114 124 PMID: 19969594

Do you know of a great paper that uses Melatonin from Tocris? Please let us know.

Reviews for Melatonin

Average Rating: 5 (Based on 1 Review.)

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Excellent choice for interaction studies with melatonin receptors.
By Benjamin Stauch on 10/11/2022
Assay Type: In Vitro
Species: Human

This product is an excellent choice for in vitro interaction studies with melatonin receptors. Given that its the endogenous ligand of these receptors, it offers an important point of comparison when testing ligands with unknown activity profiles. In our lab, we typically use this product in micromolar concentrations in all buffers when handling melatonin receptors, unless a more highly stabilizing or potent ligand (such as 2-phenylmelatonin or ramelteon) is needed. These ligands can be more expensive, making melatonin preferable in some cases. We found this product consistently of the highest quality. Highly recommended

PMID: 31019306