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Cat.No. 3550 - Melatonin | C13H16N2O2 | CAS No. 73-31-4
Description: Endogenous hormone; agonist at MT1 and MT2
Chemical Name: N-Acetyl-5-methoxytryptamine
Purity: ≥99% (HPLC)
Citations (7)
Literature (1)

Biological Activity for Melatonin

Melatonin is an endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.

Compound Libraries for Melatonin

Melatonin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Melatonin

M. Wt 232.28
Formula C13H16N2O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 73-31-4
PubChem ID 896
Smiles O=C(C)NCCC2=CNC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Melatonin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.61 50

Preparing Stock Solutions for Melatonin

The following data is based on the product molecular weight 232.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.61 mL 43.05 mL 86.1 mL
2.5 mM 1.72 mL 8.61 mL 17.22 mL
5 mM 0.86 mL 4.31 mL 8.61 mL
25 mM 0.17 mL 0.86 mL 1.72 mL

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References for Melatonin

References are publications that support the biological activity of the product.

Bubenik (2008) Thirty four years since the discovery of gastrointestinal melatonin. J.Physiol.Pharmacol. 59 33 PMID: 18812627

Fischer et al (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp.Dermatol. 17 713 PMID: 18643846

Cardinali et al (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int.J.Neurosci. 119 821 PMID: 19326288

If you know of a relevant reference for Melatonin, please let us know.

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Keywords: Melatonin, Melatonin supplier, Endogenous, hormone, agonists, MT1, MT2, Receptors, Melatonin, circadian, rhythms, (MT), 3550, Tocris Bioscience

7 Citations for Melatonin

Citations are publications that use Tocris products. Selected citations for Melatonin include:

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Toxicol Sci 20 1298 PMID: 24574803

Giordano et al (2008) Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol Appl Pharmacol 232 161 PMID: 18656495

Fernandes et al (2019) Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression. Front Cell Infect Microbiol 9 60 PMID: 30949455

Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754

Do you know of a great paper that uses Melatonin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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