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Melatonin

Cat. No. 3550 5 Citations Submit a Review Datasheet / COA / SDS
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Cat.No. 3550 - Melatonin | C13H16N2O2 | CAS No. 73-31-4
Description: Endogenous hormone; agonist at MT1 and MT2
Chemical Name: N-Acetyl-5-methoxytryptamine
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.

Compound Libraries

Melatonin is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 232.28
Formula C13H16N2O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 73-31-4
PubChem ID 896
InChI Key DRLFMBDRBRZALE-UHFFFAOYSA-N
Smiles O=C(C)NCCC2=CNC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.61 50

Preparing Stock Solutions

The following data is based on the product molecular weight 232.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.61 mL 43.05 mL 86.1 mL
2.5 mM 1.72 mL 8.61 mL 17.22 mL
5 mM 0.86 mL 4.31 mL 8.61 mL
25 mM 0.17 mL 0.86 mL 1.72 mL

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References

References are publications that support the biological activity of the product.

Bubenik (2008) Thirty four years since the discovery of gastrointestinal melatonin. J.Physiol.Pharmacol. 59 33 PMID: 18812627

Fischer et al (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp.Dermatol. 17 713 PMID: 18643846

Cardinali et al (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int.J.Neurosci. 119 821 PMID: 19326288

If you know of a relevant reference for Melatonin, please let us know.

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Keywords: Melatonin, Melatonin supplier, Endogenous, hormone, agonists, MT1, MT2, Receptors, Melatonin, circadian, rhythms, (MT), 3550, Tocris Bioscience

5 Citations for Melatonin

Citations are publications that use Tocris products. Selected citations for Melatonin include:

Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Toxicol Sci 20 1298 PMID: 24574803

Giordano et al (2008) Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol Appl Pharmacol 232 161 PMID: 18656495

Huang et al (2010) Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons. Nature 114 124 PMID: 19969594

Costa et al (2015) The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice. Neurotoxicology 48 68 PMID: 25797475

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Literature in this Area

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