Endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 232.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.31 mL||21.53 mL||43.05 mL|
|5 mM||0.86 mL||4.31 mL||8.61 mL|
|10 mM||0.43 mL||2.15 mL||4.31 mL|
|50 mM||0.09 mL||0.43 mL||0.86 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bubenik (2008) Thirty four years since the discovery of gastrointestinal melatonin. J.Physiol.Pharmacol. 59 33 PMID: 18812627
Fischer et al (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp.Dermatol. 17 713 PMID: 18643846
Cardinali et al (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int.J.Neurosci. 119 821 PMID: 19326288
If you know of a relevant reference for Melatonin, please let us know.
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Keywords: Endogenous hormone agonists MT1 MT2 Receptors Melatonin circadian rhythms Melatonin (MT) Receptors
2 Citations for Melatonin
Citations are publications that use Tocris products. Selected citations for Melatonin include:
Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Toxicol Sci 20 1298 PMID: 24574803
Huang et al (2010) Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons. Nature 114 124 PMID: 19969594
Do you know of a great paper that uses Melatonin from Tocris? If so please let us know.