Medetomidine hydrochloride

Discontinued Product

Cat.No. 2023 - Medetomidine hydrochloride | C13H16N2.HCl | CAS No. 86347-15-1
Description: Potent, highly selective α2 agonist
Chemical Name: 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Technical Data

M. Wt 236.74
Formula C13H16N2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 86347-15-1
Smiles Cl.CC(C1=CN=CN1)C1=C(C)C(C)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 236.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.22 mL 21.12 mL 42.24 mL
5 mM 0.84 mL 4.22 mL 8.45 mL
10 mM 0.42 mL 2.11 mL 4.22 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9 PMID: 2900154

Savola et al (1986) Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 6 275 PMID:

Scheinin et al (1989) Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635 PMID:

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Keywords: Potent selective α2-adrenoceptor alpha2-adrenoceptor a2-adrenoceptor α2-Adrenergic alpha2-Adrenergic a2-adrenergic agonists Receptors Adrenergic Alpha-2 Receptors

Citations for Medetomidine hydrochloride

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Currently there are no citations for Medetomidine hydrochloride.

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