MDL 72832 hydrochloride

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Cat.No. 0412 - MDL 72832 hydrochloride | C22H30N2O4.HCl | CAS No. 113777-40-5
Description: Potent 5-HT1A ligand
Chemical Name: 8-[4-(1,4-Benzodioxan-2-ylmethylamino)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

A potent ligand at 5-HT1A receptors, with mixed agonist and antagonist properties. An agonist at post-synaptic 5-HT1A receptors.

Technical Data

M. Wt 422.95
Formula C22H30N2O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 113777-40-5
PubChem ID 45073438
InChI Key GQGDGISNRPBRSG-UHFFFAOYSA-N
Smiles Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 422.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.82 mL 23.64 mL
5 mM 0.47 mL 2.36 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Millan et al (1993) Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat - a pharmacological characterization of the actions of novel agonists and antagonists. J.Pharmacol.Exp.Ther. 264 1364 PMID: 8450471

Mir et al (1988) MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. Eur.J.Pharmacol. 149 107 PMID: 2840295


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Pathways for MDL 72832 hydrochloride

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