MDL 72527

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Cat.No. 3709 - MDL 72527 | C12H20N2.2HCl | CAS No. 93565-01-6
Description: Polyamine oxidase (PAO) inhibitor
Chemical Name: N1,N4-Di-2,3-butadienyl-1,4-butanediamine dihydrochloride
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Literature

Biological Activity

Polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo.

Technical Data

M. Wt 265.23
Formula C12H20N2.2HCl
Storage Desiccate at +4°C
CAS Number 93565-01-6
PubChem ID 3035046
InChI Key ITVRWVVFVHINOH-UHFFFAOYSA-N
Smiles C=C=CCNCCCCNCC=C=C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.52 100
DMSO 19.89 75

Preparing Stock Solutions

The following data is based on the product molecular weight 265.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.7 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.89 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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References

References are publications that support the biological activity of the product.

Bey et al (1985) N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J.Med.Chem. 28 1 PMID: 3965702

Dogan et al (1999) Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J.Neurochem. 72 765 PMID: 9930751

Basu et al (2009) A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 69 7689 PMID: 19773450


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Keywords: MDL 72527, MDL 72527 supplier, MDL72527, polyamine, oxidases, inhibitors, inhibits, POA, Other, Oxygenases/Oxidases, 3709, Tocris Bioscience

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