You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for MDL 29951
Potent, selective antagonist at the glycine-NMDA site (IC50 = 140 nM against glycine binding). Displays 2500-fold selectivity for the glycine vs. glutamate binding site.
Technical Data for MDL 29951
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDL 29951
References for MDL 29951
References are publications that support the biological activity of the product.
Salituro et al (1992) 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-MthD.-aspartic acid receptor associated glycine binding site. J.Med.Chem. 35 1791 PMID: 1534125
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291
Rowley et al (1992) Synthesis of cis-4-amido and trans-4-amido 2-carboxytetrahydroquinolines, high affinity ligands at the glycine site of the NMDA receptor. Bioorg.Med.Chem.Lett. 371 1627
View Related Products by Product Action
Keywords: MDL 29951, MDL 29951 supplier, NMDA, Receptors, 0467, Tocris Bioscience
Citations for MDL 29951
Citations are publications that use Tocris products.
Currently there are no citations for MDL 29951.
Reviews for MDL 29951
There are currently no reviews for this product. Be the first to review MDL 29951 and earn rewards!
Have you used MDL 29951?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Stem Cells
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.