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Biological Activity for MDL 29951
Potent, selective antagonist at the glycine-NMDA site (IC50 = 140 nM against glycine binding). Displays 2500-fold selectivity for the glycine vs. glutamate binding site.
Technical Data for MDL 29951
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDL 29951
References for MDL 29951
References are publications that support the biological activity of the product.
Salituro et al (1992) 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-MthD.-aspartic acid receptor associated glycine binding site. J.Med.Chem. 35 1791 PMID: 1534125
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291
Rowley et al (1992) Synthesis of cis-4-amido and trans-4-amido 2-carboxytetrahydroquinolines, high affinity ligands at the glycine site of the NMDA receptor. Bioorg.Med.Chem.Lett. 371 1627
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Keywords: MDL 29951, MDL 29951 supplier, NMDA, Receptors, 0467, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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- Stem Cells
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Huntington's Disease PosterUpdated
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Learning & Memory Poster
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
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