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Discontinued Product
MDL 29951 (Cat. No. 0467) has been withdrawn from sale for commercial reasons.
Description: NMDA antagonist, acts glycine site
Chemical Name: 2-Carboxy-4,6-dichloro-(1H)-indole-3-propanoic acid
Biological Activity for MDL 29951
Potent, selective antagonist at the glycine-NMDA site (IC50 = 140 nM against glycine binding). Displays 2500-fold selectivity for the glycine vs. glutamate binding site.
Technical Data for MDL 29951
| M. Wt | 302.11 |
| Storage | Store at RT |
| CAS Number | 130798-51-5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDL 29951
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
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References for MDL 29951
References are publications that support the biological activity of the product.
Salituro et al (1992) 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-MthD.-aspartic acid receptor associated glycine binding site. J.Med.Chem. 35 1791 PMID: 1534125
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291
Rowley et al (1992) Synthesis of cis-4-amido and trans-4-amido 2-carboxytetrahydroquinolines, high affinity ligands at the glycine site of the NMDA receptor. Bioorg.Med.Chem.Lett. 371 1627
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Keywords: MDL 29951, MDL 29951 supplier, NMDA, Receptors, 0467, Tocris Bioscience
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