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Submit ReviewMDA 19
Description: CB2 agonist
Chemical Name: N'-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide
Purity: ≥99% (HPLC)
Biological Activity for MDA 19
MDA 19 is a CB2 receptor agonist. Displays 4-fold higher affinity for the human CB2 receptor than the human CB1 receptor (Ki values are 43.3 and 162.4 nM respectively); shows 70-fold affinity for the rat CB2 receptor over the rat CB1 receptor (Ki values are 16.3 and 1130 nM respectively). Attenuates tactile allodynia in a rat model; does not affect rat locomotor activity.
Technical Data for MDA 19
| M. Wt | 349.43 |
| Formula | C21H23N3O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1048973-47-2 |
| PubChem ID | 25034599 |
| InChI Key | ZGQHMZCITJHYOW-QOCHGBHMSA-N |
| Smiles | O=C(C3=CC=CC=C3)N\N=C(C1=CC=CC=C1N2CCCCCC)/C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDA 19
References for MDA 19
References are publications that support the biological activity of the product.
Diaz et al (2008) Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain. J.Med.Chem. 51 4932 PMID: 18666769
Xu et al (2010) Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. Anesth.Analg. 111 99 PMID: 20522703
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Keywords: MDA 19, MDA 19 supplier, MDA19, cb2, cannabinoid, agonists, CB2, Receptors, 4205, Tocris Bioscience
Citations for MDA 19
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Currently there are no citations for MDA 19.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.