MDA 19

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Cat.No. 4205 - MDA 19 | C21H23N3O2 | CAS No. 1048973-47-2
Description: CB2 agonist
Chemical Name: N'-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

CB2 receptor agonist. Displays 4-fold higher affinity for the human CB2 receptor than the human CB1 receptor (Ki values are 43.3 and 162.4 nM respectively); shows 70-fold affinity for the rat CB2 receptor over the rat CB1 receptor (Ki values are 16.3 and 1130 nM respectively). Attenuates tactile allodynia in a rat model; does not affect rat locomotor activity.

Technical Data

M. Wt 349.43
Formula C21H23N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1048973-47-2
PubChem ID 25034599
InChI Key ZGQHMZCITJHYOW-QOCHGBHMSA-N
Smiles O=C(C3=CC=CC=C3)N\N=C(C1=CC=CC=C1N2CCCCCC)/C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.47 50
ethanol 17.47 50

Preparing Stock Solutions

The following data is based on the product molecular weight 349.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.72 mL 28.62 mL 57.24 mL
2.5 mM 1.14 mL 5.72 mL 11.45 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
25 mM 0.11 mL 0.57 mL 1.14 mL

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References

References are publications that support the biological activity of the product.

Diaz et al (2008) Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain. J.Med.Chem. 51 4932 PMID: 18666769

Xu et al (2010) Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. Anesth.Analg. 111 99 PMID: 20522703


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Citations for MDA 19

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