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Biological Activity for MDA 19
MDA 19 is a CB2 receptor agonist. Displays 4-fold higher affinity for the human CB2 receptor than the human CB1 receptor (Ki values are 43.3 and 162.4 nM respectively); shows 70-fold affinity for the rat CB2 receptor over the rat CB1 receptor (Ki values are 16.3 and 1130 nM respectively). Attenuates tactile allodynia in a rat model; does not affect rat locomotor activity.
Technical Data for MDA 19
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for MDA 19
References are publications that support the biological activity of the product.
Diaz et al (2008) Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain. J.Med.Chem. 51 4932 PMID: 18666769
Xu et al (2010) Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. Anesth.Analg. 111 99 PMID: 20522703
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Keywords: MDA 19, MDA 19 supplier, MDA19, cb2, cannabinoid, agonists, CB2, Receptors, 4205, Tocris Bioscience
Citations for MDA 19
Citations are publications that use Tocris products.
Currently there are no citations for MDA 19.
Reviews for MDA 19
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Literature in this Area
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