MDA 19

Pricing Availability Delivery Time Qty
Cat.No. 4205 - MDA 19 | C21H23N3O2 | CAS No. 1048973-47-2
Description: CB2 agonist
Chemical Name: N'-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide
Purity: ≥99% (HPLC)

Biological Activity

CB2 receptor agonist. Displays 4-fold higher affinity for the human CB2 receptor than the human CB1 receptor (Ki values are 43.3 and 162.4 nM respectively); shows 70-fold affinity for the rat CB2 receptor over the rat CB1 receptor (Ki values are 16.3 and 1130 nM respectively). Attenuates tactile allodynia in a rat model; does not affect rat locomotor activity.

Technical Data

M. Wt 349.43
Formula C21H23N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1048973-47-2
PubChem ID 25034599
Smiles O=C(C3=CC=CC=C3)N\N=C(C1=CC=CC=C1N2CCCCCC)/C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.47 50
ethanol 17.47 50

Preparing Stock Solutions

The following data is based on the product molecular weight 349.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Diaz et al (2008) Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain. J.Med.Chem. 51 4932 PMID: 18666769

Xu et al (2010) Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. Anesth.Analg. 111 99 PMID: 20522703

If you know of a relevant reference for MDA 19, please let us know.

View Related Products by Target

View Related Products by Product Action

View all CB2 Receptor Agonists

Keywords: MDA 19, supplier, MDA19, cb2, cannabinoid, agonists, CB2, Receptors, CB2, Receptors, Tocris Bioscience

Citations for MDA 19

Citations are publications that use Tocris products.

Currently there are no citations for MDA 19. Do you know of a great paper that uses MDA 19 from Tocris? If so please let us know.

Reviews for MDA 19

There are currently no reviews for this product. Be the first to review MDA 19 and earn rewards!

Have you used MDA 19?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.