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MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 377.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.65 mL||13.25 mL||26.49 mL|
|5 mM||0.53 mL||2.65 mL||5.3 mL|
|10 mM||0.26 mL||1.32 mL||2.65 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
References are publications that support the biological activity of the product.
Di Marco et al (2020) A high-throughput screening identifies MICU1 targeting compounds. Cell Rep. 30 2321 PMID: 32075766
If you know of a relevant reference for MCU i4, please let us know.
Keywords: MCU i4, MCU i4 supplier, MCUi4, MCU, mitochondrial, calcium, ca2+, uniporter, complex, negative, modulators, inhibitors, inhibits, modulates, MICU1, Mitochondrial, Calcium, Uniporter, 7195, Tocris Bioscience
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