MCU i4

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Cat.No. 7195 - MCU i4 | C23H27N3O2 | CAS No. 371924-24-2
Description: Negative modulator of mitochondrial Ca2+ uniporter (MCU)
Chemical Name: 4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for MCU i4

MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.

Technical Data for MCU i4

M. Wt 377.49
Formula C23H27N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 371924-24-2
PubChem ID 1568449
InChI Key RIWXBJCWHVMATR-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C(NC2=CC=C(C=C2)N(CC)CC)C2=C(C=CC(C)=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MCU i4

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.87 50
ethanol 37.75 100

Preparing Stock Solutions for MCU i4

The following data is based on the product molecular weight 377.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.49 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References for MCU i4

References are publications that support the biological activity of the product.

Di Marco et al (2020) A high-throughput screening identifies MICU1 targeting compounds. Cell Rep. 30 2321 PMID: 32075766


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Keywords: MCU i4, MCU i4 supplier, MCUi4, MCU, mitochondrial, calcium, ca2+, uniporter, complex, negative, modulators, inhibitors, inhibits, modulates, MICU1, Mitochondrial, Calcium, Uniporter, 7195, Tocris Bioscience

Citations for MCU i4

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Literature in this Area

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