MBCQ

Discontinued Product

Unfortunately MBCQ (Cat. No. 0874) has been withdrawn from sale for commercial reasons.
Cat.No. 0874 - MBCQ
Description: PDE5 inhibitor
Chemical Name: 4-[[3,4-(Methylenedioxy)benzyl]amino]-6-chloroquinazoline
Datasheet
Citations
Reviews
Literature

Biological Activity

Very selective inhibitor of cGMP-specific phosphodiesterase (PDE5) (IC50 = 0.019 μM).

Technical Data

M. Wt 313.74
Storage Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 313.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.94 mL 31.87 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Sampson et al (2001) Evidence for expression and function of phosphodiesterase type 5 (PDE-V) in rat resistance arteries. Br.J.Pharmacol. 132 13 PMID: 11156556

Takase et al (1994) Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-subsitution of quinazoline derivatives for potent and selective inhibitory activity. J.Med.Chem. 37 2106 PMID: 8027992

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Keywords: MBCQ, supplier, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

Citations for MBCQ

Citations are publications that use Tocris products.

Currently there are no citations for MBCQ.

Reviews for MBCQ

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

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