Mastoparan

Pricing Availability Delivery Time Qty
Cat.No. 1192 - Mastoparan | Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2 | CAS No. 72093-21-1
Description: Activates Gi and Go
Datasheet
Citations
Literature

Biological Activity

Peptide activator of Gi and Go.

Technical Data

M. Wt 1479
Formula C70H131N19O15
Sequence INLKALAALAKKIL

(Modifications: Leu-14 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 72093-21-1
PubChem ID 6324633
InChI Key MASXKPLGZRMBJF-MVSGICTGSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1479. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.68 mL 3.38 mL 6.76 mL
5 mM 0.14 mL 0.68 mL 1.35 mL
10 mM 0.07 mL 0.34 mL 0.68 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Higashijima and Ros (1991) Mapping of the mastoparan-binding site on G proteins. Cross-linking of [125I-Tyr3,Cys11]mastoparan to Go. J.Biol.Chem. 266 12655 PMID: 1905730

Longland et al (1999) The mechanism of inhibition of the Ca2+-ATPase by mastoparan. J.Biol.Chem. 274 14799 PMID: 10329678

Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. TiPS 11 358 PMID: 2122563

Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 266 2753 PMID: 1847132


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Keywords: Activator Gi Go Gi/o G-Protein Signaling Signalling Heterotrimeric G Protein (Heterotrimeric)

Citations for Mastoparan

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Literature in this Area

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Pathways for Mastoparan

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