Mastoparan X

Discontinued Product

Unfortunately Mastoparan X (Cat. No. 1896) has been withdrawn from sale for commercial reasons.
Cat.No. 1896 - Mastoparan X | Ile-Asn-Trp-Lys-Gly-Ile-Ala-Ala-Met-Ala-Lys-Lys-Leu-Leu-NH2 | CAS No. 72093-22-2
Description: G protein activator peptide

Biological Activity

Amphiphilic G protein activator peptide that binds to Gi and Go. Also binds with high affinity to calmodulin (Kd ~ 0.9 nM) and inhibits sarcoplasmic reticulum Ca2+-ATPase (Ki = 4.4 mM).

Technical Data

M. Wt 1555.98
Formula C73H126N20O15S

(Modifications: Leu-14 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 72093-22-2
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1555.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.21 mL 6.43 mL
5 mM 0.13 mL 0.64 mL 1.29 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Higashijima et al (1990) Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. J.Biol.Chem. 265 14176 PMID: 2117607

Longland et al (1999) The mechanism of inhibition of the Ca2+-ATPase by mastoparan. J.Biol.Chem. 274 14799 PMID: 10329678

Sukumar and Higashijima (1992) G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide. J.Biol.Chem. 267 21421 PMID: 1400455

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Keywords: Mastoparan X, supplier, G, protein, activators, peptide, Gi, Go, Heterotrimeric, MastoparanX, G, Protein, (Heterotrimeric), G, Protein, (Heterotrimeric), Tocris Bioscience

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