Maprotiline hydrochloride

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Cat.No. 0935 - Maprotiline hydrochloride | C20H23N.HCl | CAS No. 10347-81-6
Description: Noradrenalin re-uptake inhibitor
Chemical Name: 1-(3-Methylaminopropyl)dibenzo[b,e]bicyclo[2.2.2]octadiene hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Selective noradrenalin re-uptake inhibitor.

Technical Data

M. Wt 313.87
Formula C20H23N.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 10347-81-6
PubChem ID 71478
Smiles Cl.CNCCCC12CCC(C3=CC=CC=C13)C1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in ethanol and to 10 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 313.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Pawlowski and Nowak (1987) Biochemical and pharmacological tests for the prediction of ability of monoamine uptake blockers to inhibit the uptake of noradrenaline in-vivo: the effects of desipramine, maprotiline, femoxetine and citalopram. J.Pharm.Pharmacol. 39 1003 PMID: 2894425

Pinder et al (1977) Maprotiline: A review of its pharmacological properties and therapeutic efficacy in mental depressive states. Drugs 13 321 PMID: 326531

Rodgers et al (1997) Behavioural effects in mice of subchronic chlordiazepoxide, maprotiline and fluvoxamine. II. The elevated plus-maze. Pharmacol.Biochem.Behav. 57 127 PMID: 9164563

Merck Index 11 5633 PMID:

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