MAFP

Discontinued Product

MAFP (Cat. No. 1421) has been withdrawn from sale for commercial reasons.
Cat.No. 1421 - MAFP | C21H36FO2P | CAS No. 188404-10-6
Description: Potent, irreversible FAAH inhibitor
Chemical Name: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).

Technical Data

M. Wt 370.49
Formula C21H36FO2P
Storage Desiccate at -80°C
CAS Number 188404-10-6
Smiles CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCP(F)(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

De Petrocellis et al (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem.Biophys.Res.Commun. 231 82 PMID: 9070224

Deutsch et al (1997) Methyl arachidonyl fluorophosphate: a potent irreversible inhibitor of anandamide amidase. Biochem.Pharmacol. 53 255 PMID: 9065728

Martin et al (2000) Cannabinoid properties of methylfluorophosphonate analogs. J.Pharmacol.Exp.Ther. 294 1209 PMID: 10945879

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Keywords: MAFP, MAFP supplier, Potent, irreversible, FAAH, inhibitors, inhibits, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, Cannabinoids, Receptors, Other, Hydrolase, (FAAH), 1421, Tocris Bioscience

Citations for MAFP

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Currently there are no citations for MAFP.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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