Discontinued Product

Unfortunately MAFP (Cat. No. 1421) has been withdrawn from sale for commercial reasons.
Cat.No. 1421 - MAFP | C21H36FO2P | CAS No. 188404-10-6
Description: Potent, irreversible FAAH inhibitor
Chemical Name: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid

Biological Activity

Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).

Technical Data

M. Wt 370.49
Formula C21H36FO2P
Storage Desiccate at -80°C
CAS Number 188404-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 370.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.5 mL 26.99 mL
5 mM 0.54 mL 2.7 mL 5.4 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

De Petrocellis et al (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem.Biophys.Res.Commun. 231 82 PMID: 9070224

Deutsch et al (1997) Methyl arachidonyl fluorophosphate: a potent irreversible inhibitor of anandamide amidase. Biochem.Pharmacol. 53 255 PMID: 9065728

Martin et al (2000) Cannabinoid properties of methylfluorophosphonate analogs. J.Pharmacol.Exp.Ther. 294 1209 PMID: 10945879

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Keywords: Potent irreversible FAAH inhibitors inhibits Anandamide Amidase Fatty Acid Amide Hydrolases Cannabinoids Receptors Other Cannabinoids

Citations for MAFP

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Pathways for MAFP


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