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MA 2029

Cat. No. 4934 Submit a Review Datasheet / COA / SDS
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Cat.No. 4934 - MA 2029 | C31H45FN4O4 | CAS No. 287206-61-5
Description: Potent and selective, competitive motilin receptor antagonist; orally active
Chemical Name: 4-Fluoro-N-methyl-L-phenylalanyl-N-methyl-L-valyl-3-(1,1-dimethylethyl)-N-ethyl-L-tyrosinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective, competitive motilin receptor antagonist (IC50 = 4.9 nM). Selective for the motilin receptor over a range of other receptors and ion channels. Inhibits motilin-induced duodenal muscle contractions in vitro. Also inhibits motilin-induced colonic and abdominal contractions in vivo. Orally active.

Technical Data

M. Wt 556.71
Formula C31H45FN4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 287206-61-5
PubChem ID 10144175
InChI Key KSDWAJPUTRBIRR-KLJDGLGGSA-N
Smiles FC1=CC=C(C[C@H](NC)C(N(C)[C@@H]([C@H](C)C)C(N[C@@H](CC2=CC=C(O)C(C(C)(C)C)=C2)[C@@](NCC)=O)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 11.13 20
DMSO 55.67 100

Preparing Stock Solutions

The following data is based on the product molecular weight 556.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.8 mL 8.98 mL 17.96 mL
5 mM 0.36 mL 1.8 mL 3.59 mL
10 mM 0.18 mL 0.9 mL 1.8 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References

References are publications that support the biological activity of the product.

Sudo et al (2008) Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur.J.Pharmacol. 581 296 PMID: 18164286

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Citations for MA 2029

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