MA 2029

Discontinued Product

MA 2029 (Cat. No. 4934) has been withdrawn from sale for commercial reasons.
Description: Potent and selective, competitive motilin receptor antagonist; orally active
Chemical Name: 4-Fluoro-N-methyl-L-phenylalanyl-N-methyl-L-valyl-3-(1,1-dimethylethyl)-N-ethyl-L-tyrosinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for MA 2029

MA 2029 is a potent and selective, competitive motilin receptor antagonist (IC50 = 4.9 nM). Selective for the motilin receptor over a range of other receptors and ion channels. Inhibits motilin-induced duodenal muscle contractions in vitro. Also inhibits motilin-induced colonic and abdominal contractions in vivo. Orally active.

Technical Data for MA 2029

M. Wt 556.71
Formula C31H45FN4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 287206-61-5
PubChem ID 10144175
InChI Key KSDWAJPUTRBIRR-KLJDGLGGSA-N
Smiles FC1=CC=C(C[C@H](NC)C(N(C)[C@@H]([C@H](C)C)C(N[C@@H](CC2=CC=C(O)C(C(C)(C)C)=C2)[C@@](NCC)=O)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for MA 2029

References are publications that support the biological activity of the product.

Sudo et al (2008) Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur.J.Pharmacol. 581 296 PMID: 18164286

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Keywords: MA 2029, MA 2029 supplier, MA2029, potent, selective, competitive, motilin, receptors, antagonists, Motilin, Receptors, 4934, Tocris Bioscience

Citations for MA 2029

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Currently there are no citations for MA 2029.

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