m-Chlorophenylbiguanide hydrochloride

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Cat.No. 0440 - m-Chlorophenylbiguanide hydrochloride | C8H10ClN5.HCl | CAS No. 2113-05-5
Description: Potent and selective 5-HT3 agonist
Chemical Name: 1-(3-Chlorophenyl)biguanide hydrochloride
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity

Prototypical potent and selective 5-HT3 receptor agonist.

Technical Data

M. Wt 248.11
Formula C8H10ClN5.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2113-05-5
PubChem ID 2730228
Smiles Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 24.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.15 mL 40.3 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
10 mM 0.4 mL 2.02 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Boess et al (1992) 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 31 561 PMID: 1407396

Kilpatrick et al (1990) 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist. Eur.J.Pharmacol. 182 193 PMID: 2144822

Niemeyer and Lummis (1998) Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 123 661 PMID: 9517385

Sepulveda et al (1991) The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 104 536 PMID: 1797317

If you know of a relevant reference for m-Chlorophenylbiguanide hydrochloride, please let us know.

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4 Citations for m-Chlorophenylbiguanide hydrochloride

Citations are publications that use Tocris products. Selected citations for m-Chlorophenylbiguanide hydrochloride include:

Dale et al (2014) Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891 PMID: 25122043

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. PLoS One 29 13909 PMID: 19890001

Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700 PMID: 18669621

Do you know of a great paper that uses m-Chlorophenylbiguanide hydrochloride from Tocris? If so please let us know.

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.