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Prototypical potent and selective 5-HT3 receptor agonist.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 248.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.03 mL||20.15 mL||40.3 mL|
|5 mM||0.81 mL||4.03 mL||8.06 mL|
|10 mM||0.4 mL||2.02 mL||4.03 mL|
|50 mM||0.08 mL||0.4 mL||0.81 mL|
References are publications that support the biological activity of the product.
Boess et al (1992) 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 31 561 PMID: 1407396
Kilpatrick et al (1990) 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist. Eur.J.Pharmacol. 182 193 PMID: 2144822
Niemeyer and Lummis (1998) Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 123 661 PMID: 9517385
Sepulveda et al (1991) The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 104 536 PMID: 1797317
If you know of a relevant reference for m-Chlorophenylbiguanide hydrochloride, please let us know.
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Keywords: m-Chlorophenylbiguanide hydrochloride, m-Chlorophenylbiguanide hydrochloride supplier, Potent, selective, specific, 5-HT3, agonists, Serotonin, Receptors, 0440, Tocris Bioscience
4 Citations for m-Chlorophenylbiguanide hydrochloride
Citations are publications that use Tocris products. Selected citations for m-Chlorophenylbiguanide hydrochloride include:
Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643
Dale et al (2014) Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891 PMID: 25122043
Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. PLoS One 29 13909 PMID: 19890001
Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700 PMID: 18669621
Do you know of a great paper that uses m-Chlorophenylbiguanide hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.