m-Chlorophenylbiguanide hydrochloride

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Cat.No. 0440 - m-Chlorophenylbiguanide hydrochloride | C8H10ClN5.HCl | CAS No. 2113-05-5
Description: Potent and selective 5-HT3 agonist
Chemical Name: 1-(3-Chlorophenyl)biguanide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (2)

Biological Activity

Prototypical potent and selective 5-HT3 receptor agonist.

Technical Data

M. Wt 248.11
Formula C8H10ClN5.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2113-05-5
PubChem ID 2730228
InChI Key FOWAIJYHRWFTHR-UHFFFAOYSA-N
Smiles Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.15 mL 40.3 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
10 mM 0.4 mL 2.02 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Boess et al (1992) 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 31 561 PMID: 1407396

Kilpatrick et al (1990) 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist. Eur.J.Pharmacol. 182 193 PMID: 2144822

Niemeyer and Lummis (1998) Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 123 661 PMID: 9517385

Sepulveda et al (1991) The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 104 536 PMID: 1797317


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Keywords: m-Chlorophenylbiguanide hydrochloride, m-Chlorophenylbiguanide hydrochloride supplier, Potent, selective, specific, 5-HT3, agonists, Serotonin, Receptors, 0440, Tocris Bioscience

4 Citations for m-Chlorophenylbiguanide hydrochloride

Citations are publications that use Tocris products. Selected citations for m-Chlorophenylbiguanide hydrochloride include:

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Dale et al (2014) Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891 PMID: 25122043

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. PLoS One 29 13909 PMID: 19890001

Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700 PMID: 18669621


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Ion Channel

Ion Channel Product Listing

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.