M-6434

Discontinued Product

Unfortunately M-6434 (Cat. No. 0461) has been withdrawn from sale for commercial reasons.
Cat.No. 0461 - M-6434 | C10H9CIN4O | CAS No. 77636-92-1
Description: a1 agonist
Chemical Name: 2-[(5-Chloro-2-methoxyphenyl)azo]-1H-imidazole
Datasheet
Citations
Reviews
Literature

Biological Activity

An α1-agonist; a potent orally active hypertensive.

Technical Data

M. Wt 236.66
Formula C10H9CIN4O
Storage Store at RT
CAS Number 77636-92-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dabasaki et al (1992) Antihypotensive effects of M6434, an orally active alpha-1-adrenoceptor agonist in rats. Jpn.J.Pharmacol. 59 145 PMID: 1279249

Ohnish (1981) Pharmacological properties of 2-[(5-chloro-2-methoxyphenyl)azo]-1H-imidazole (M6434). Arzneimittelforschung 9 1425 PMID: 7197948

Tsuchid (1986) Effects of midodrine on experimentally-induced postural hypotension in dogs. Arzneimittelforschung 12 1748 PMID: 2436631

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Keywords: M-6434, supplier, An, a1-agonist;, a, potent, orally, active, hypertensive., Adrenergic, Alpha-1, Receptors, Adrenergic, Alpha-1, Receptors, Tocris Bioscience

Citations for M-6434

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Reviews for M-6434

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cardiovascular

Cardiovascular Research Product Guide

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  • Ischemia/Reperfusion Injury
  • Arrhythmias
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GPCR

GPCR Product Listing

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Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.