Discontinued ProductUnfortunately M-6434 (Cat. No. 0461) has been withdrawn from sale for commercial reasons.
An α1-agonist; a potent orally active hypertensive.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 236.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.23 mL||21.13 mL||42.25 mL|
|5 mM||0.85 mL||4.23 mL||8.45 mL|
|10 mM||0.42 mL||2.11 mL||4.23 mL|
|50 mM||0.08 mL||0.42 mL||0.85 mL|
References are publications that support the products' biological activity.
Dabasaki et al (1992) Antihypotensive effects of M6434, an orally active alpha-1-adrenoceptor agonist in rats. Jpn.J.Pharmacol. 59 145 PMID: 1279249
Ohnish (1981) Pharmacological properties of 2-[(5-chloro-2-methoxyphenyl)azo]-1H-imidazole (M6434). Arzneimittelforschung 9 1425 PMID: 7197948
Tsuchid (1986) Effects of midodrine on experimentally-induced postural hypotension in dogs. Arzneimittelforschung 12 1748 PMID: 2436631
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Keywords: M-6434, supplier, An, a1-agonist;, a, potent, orally, active, hypertensive., Adrenergic, Alpha-1, Receptors, Adrenergic, Alpha-1, Receptors, Tocris Bioscience
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.