An α1-agonist; a potent orally active hypertensive.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Dabasaki et al (1992) Antihypotensive effects of M6434, an orally active alpha-1-adrenoceptor agonist in rats. Jpn.J.Pharmacol. 59 145 PMID: 1279249
Ohnish (1981) Pharmacological properties of 2-[(5-chloro-2-methoxyphenyl)azo]-1H-imidazole (M6434). Arzneimittelforschung 9 1425 PMID: 7197948
Tsuchid (1986) Effects of midodrine on experimentally-induced postural hypotension in dogs. Arzneimittelforschung 12 1748 PMID: 2436631
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Keywords: M-6434, M-6434 supplier, An, a1-agonist;, a, potent, orally, active, hypertensive., Adrenergic, Alpha-1, Receptors, 0461, Tocris Bioscience
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.