M 1145

Pricing Availability Delivery Time Qty
Cat.No. 3629 - M 1145 | Arg-Gly-Arg-Gly-Asn-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2 | CAS No. 1172089-00-7
Description: Potent and selective GAL2 agonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.

Technical Data

M. Wt 2774.26
Formula C128H205N37O32
Sequence RGRGNWTLNSAGYLLGPVLPPPALALA

(Modifications: Ala-27 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 1172089-00-7
PubChem ID 71744999
InChI Key XIHYPTIVAPJZFP-HEPWHOECSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 5 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2774.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.36 mL 1.8 mL 3.6 mL
5 mM 0.07 mL 0.36 mL 0.72 mL
10 mM 0.04 mL 0.18 mL 0.36 mL
50 mM 0.01 mL 0.04 mL 0.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Runesson et al (2009) A novel GalR2-specific peptide agonist. Neuropeptides 43 187 PMID: 19467704


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Keywords: M 1145, M 1145 supplier, Potent, selective, GAL2, GalR2, agonists, Receptors, Galanin, M1145, 3629, Tocris Bioscience

Citations for M 1145

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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