M 1145

Pricing Availability Delivery Time Qty
Cat.No. 3629 - M 1145 | Arg-Gly-Arg-Gly-Asn-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2 | CAS No. 1172089-00-7
Description: Potent and selective GAL2 agonist
Datasheet
Citations
Literature

Biological Activity

Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.

Technical Data

M. Wt 2774.26
Formula C128H205N37O32
Sequence RGRGNWTLNSAGYLLGPVLPPPALALA

(Modifications: Ala-27 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 1172089-00-7
PubChem ID 71744999
InChI Key XIHYPTIVAPJZFP-HEPWHOECSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2774.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.36 mL 1.8 mL 3.6 mL
5 mM 0.07 mL 0.36 mL 0.72 mL
10 mM 0.04 mL 0.18 mL 0.36 mL
50 mM 0.01 mL 0.04 mL 0.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Runesson et al (2009) A novel GalR2-specific peptide agonist. Neuropeptides 43 187 PMID: 19467704


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Keywords: Potent selective GAL2 GalR2 agonists Receptors Galanin M1145 Galanin Receptors

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