LY 315920

Discontinued Product

Unfortunately LY 315920 (Cat. No. 5313) has been withdrawn from sale for commercial reasons.
Cat.No. 5313 - LY 315920 | C21H20N2O5 | CAS No. 172732-68-2
Description: Selective secreted phospholipase A2 (sPLA2) inhibitor
Alternative Names: Varespladib
Chemical Name: 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic aci
Purity: ≥98% (HPLC)

Biological Activity

Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Has no effect on cytosolic PLA2 or COX-1 and COX-2 activity. Attenuates sPLA2-induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA2-induced contractions of lung pleural strips ex vivo. Orally available.

Technical Data

M. Wt 380.39
Formula C21H20N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 172732-68-2
PubChem ID 155815
Smiles OC(COC1=C2C(N(CC3=CC=CC=C3)C(CC)=C2C(C(N)=O)=O)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 380.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Snyder et al (1999) Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J.Pharmacol.Exp.Ther. 288 1117 PMID: 10027849

Oslund et al (2008) Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J.Med.Chem. 51 4708 PMID: 18605714

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Keywords: LY 315920, supplier, LY315920, selective, secreted, phospholipase, A2, sPLA2, inhibitors, inhibits, orally, available, Varespladib, Varespladib, Phospholipases, Phospholipases, Tocris Bioscience

Citations for LY 315920

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