LY 315920

Discontinued Product

LY 315920 (Cat. No. 5313) has been withdrawn from sale for commercial reasons.
Description: Selective secreted phospholipase A2 (sPLA2) inhibitor
Alternative Names: Varespladib
Chemical Name: 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic aci
Purity: ≥98% (HPLC)

Biological Activity for LY 315920

Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Has no effect on cytosolic PLA2 or COX-1 and COX-2 activity. Attenuates sPLA2-induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA2-induced contractions of lung pleural strips ex vivo. Orally available.

Technical Data for LY 315920

M. Wt 380.39
Formula C21H20N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 172732-68-2
PubChem ID 155815
Smiles OC(COC1=C2C(N(CC3=CC=CC=C3)C(CC)=C2C(C(N)=O)=O)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for LY 315920

References are publications that support the biological activity of the product.

Snyder et al (1999) Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J.Pharmacol.Exp.Ther. 288 1117 PMID: 10027849

Oslund et al (2008) Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J.Med.Chem. 51 4708 PMID: 18605714

View Related Products by Target

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: LY 315920, LY 315920 supplier, LY315920, selective, secreted, phospholipase, A2, sPLA2, inhibitors, inhibits, orally, available, Varespladib, Phospholipases, 5313, Tocris Bioscience

Citations for LY 315920

Citations are publications that use Tocris products.

Currently there are no citations for LY 315920.

Reviews for LY 315920

There are currently no reviews for this product. Be the first to review LY 315920 and earn rewards!

Have you used LY 315920?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review