LY 311727

Discontinued Product

Unfortunately LY 311727 (Cat. No. 3627) has been withdrawn from sale for commercial reasons.
Cat.No. 3627 - LY 311727 | C22H27N2O5P | CAS No. 164083-84-5
Description: Selective secreted phospholipase A2 (sPLA2) inhibitor
Chemical Name: [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonic acid
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 values are <1 μM for group IIA and <50 μM for group V). Attenuates VEGF-mediated platelet-activating factor (PAF) synthesis in BAEC and HUVEC cells at a concentration of 100 μM.

Technical Data

M. Wt 430.43
Formula C22H27N2O5P
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 164083-84-5
PubChem ID 155922
InChI Key OPWQYOUZRHDKBR-UHFFFAOYSA-N
Smiles NC(CC2=C(CC)N(CC3=CC=CC=C3)C1=CC=C(OCCCP(O)(O)=O)C=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 430.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Schevitz et al (1995) Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat.Struct.Biol. 2 429 PMID: 7664101

Bernatchez et al (2001) VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. Br.J.Pharmacol. 134 197 PMID: 11522612

Bridonneau et al (1997) High-affinity aptamers selectively inhibit human nonpancreatic secretory phospholipase A2 (hnps-PLA2). J.Med.Chem 41 778 PMID:

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Keywords: LY 311727, supplier, LY311727, secreted, phospholipases, a2, sPLA2, PLA2, inhibitors, inhibits, Phospholipases, Tocris Bioscience

1 Citation for LY 311727

Citations are publications that use Tocris products. Selected citations for LY 311727 include:

Mock et al (2013) Evidence for distinct mechanisms of uptake and antitumor activity of secretory phospholipase A2 responsive liposome in prostate cancer. Integr Biol (Camb) 5 172 PMID: 22890797


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