LY 255283

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Cat.No. 2208 - LY 255283 | C19H28N4O3 | CAS No. 117690-79-6
Description: Selective, competitive BLT2 receptor antagonist
Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration. .

Compound Libraries

LY 255283 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 360.46
Formula C19H28N4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 117690-79-6
PubChem ID 122023
InChI Key WCGXJPFHTHQNJL-UHFFFAOYSA-N
Smiles CCC1=C(OCCCCCC(C)(C)C2=NN=NN2)C=C(O)C(=C1)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.05 100
ethanol 9.01 25

Preparing Stock Solutions

The following data is based on the product molecular weight 360.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Herron et al (1992) Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 35 1818 PMID: 1316967

Silbaugh et al (1992) Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 223 57 PMID: 1335877

Yokomizo et al (2001) Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J.Biol.Chem. 276 12454 PMID: 11278893


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View all Leukotriene and Related Receptor Antagonists

Keywords: Selective competitive BLT2 receptor antagonists CysLT1 Receptors CysLT2 BLT1 OXE Oxoeicosanoid receptors LTD4 LTE4 leukotrienes eicosanoids LY255283 Leukotriene and Related Receptors

1 Citation for LY 255283

Citations are publications that use Tocris products. Selected citations for LY 255283 include:

Cabral et al (2015) Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PLoS One 3 PMID: 26216432


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Pathways for LY 255283

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