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Submit ReviewLY 231617
Description: Antioxidant; neuroprotective in vitro and in vivo
Chemical Name: 2,6-bis(1,1-Dimethylethyl)-4-[(ethylamino)methyl]phenol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Antioxidant; protects against ischemia-induced neuronal damage in rat models of global and focal cerebral ischemia. Neuroprotective in vitro and in vivo.
Technical Data
| M. Wt | 299.88 |
| Formula | C17H29NO.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 141545-89-3 |
| PubChem ID | 178576 |
| InChI Key | SIWZKGFBUXQFDK-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CNCC)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.99 | 100 | |
| ethanol | 29.99 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 299.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.67 mL | 33.35 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.67 mL |
| 10 mM | 0.33 mL | 1.67 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Clemens et al (1993) The antioxidant LY 231617 reduces global ischemic neuronal injury in rats. Stroke 24 716 PMID: 8488528
Fuson et al (1999) Characterization of LY 231617 protection against hydrogen peroxide toxicity. J.Neurochem. 72 1154 PMID: 10037488
O'Neill et al (1997) Neuroprotective effects of the antioxidant LY 231617 and NO synthase inhibitors in global ischaemia. Brain Res. 760 170 PMID: 9237532
If you know of a relevant reference for LY 231617, please let us know.
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