LY 231617

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Cat.No. 1286 - LY 231617 | C17H29NO.HCl | CAS No. 141545-89-3
Description: Antioxidant; neuroprotective in vitro and in vivo
Chemical Name: 2,6-bis(1,1-Dimethylethyl)-4-[(ethylamino)methyl]phenol hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Antioxidant; protects against ischemia-induced neuronal damage in rat models of global and focal cerebral ischemia. Neuroprotective in vitro and in vivo.

Technical Data

M. Wt 299.88
Formula C17H29NO.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 141545-89-3
PubChem ID 178576
Smiles CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CNCC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.99 100
ethanol 29.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 299.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.67 mL 33.35 mL
5 mM 0.67 mL 3.33 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References are publications that support the biological activity of the product.

Clemens et al (1993) The antioxidant LY 231617 reduces global ischemic neuronal injury in rats. Stroke 24 716 PMID: 8488528

Fuson et al (1999) Characterization of LY 231617 protection against hydrogen peroxide toxicity. J.Neurochem. 72 1154 PMID: 10037488

O'Neill et al (1997) Neuroprotective effects of the antioxidant LY 231617 and NO synthase inhibitors in global ischaemia. Brain Res. 760 170 PMID: 9237532

If you know of a relevant reference for LY 231617, please let us know.

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