LY 225910

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Cat.No. 1018 - LY 225910 | C27H24BrN3O2 | CAS No. 133040-77-4
Description: Potent CCK2 antagonist
Chemical Name: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline
Datasheet
Citations (3)
Literature

Biological Activity

Potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes).

Licensing Information

Sold with the permission of Eli Lilly and Company.

Compound Libraries

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Technical Data

M. Wt 502.41
Formula C27H24BrN3O2
Storage Desiccate at -20°C
CAS Number 133040-77-4
PubChem ID 4355450
InChI Key KUECXUACQOYKNB-UHFFFAOYSA-N
Smiles CC(C)OC1=CC=CC(=C1)N1C(CCC2=CNC3=CC=C(Br)C=C23)=NC2=C(C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 502.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.95 mL 19.9 mL
5 mM 0.4 mL 1.99 mL 3.98 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Suman-Chauhan et al (1996) The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [3H]PD140376. Regul.Pept. 65 37 PMID: 8876034

Yu et al (1991) Quinazolinone cholecystokinin receptor ligands. J.Med.Chem. 34 1505 PMID: 2016728


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Keywords: LY 225910, supplier, Potent, CCK2, antagonists, Cholecystokinin2, Receptors, LY225910, CCK2, Receptor, Tocris Bioscience

3 Citations for LY 225910

Citations are publications that use Tocris products. Selected citations for LY 225910 include:

Karson et al (2008) Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. J Card Fail 54 117 PMID: 17689570

Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. Neuropsychopharmacology 16 1440 PMID: 16339088

Seillier et al (2013) Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia. Neuropharmacology 38 1816 PMID: 23563893


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