Partial agonist of hydroxycarboxylic acid receptor 2 (HCA2) (Ki = 0.55 μM). Thought to lower plasma very-low-density lipoprotein (VLDL)-triglyceride levels by affecting hepatic VLDL production in normolipidemic C57BL/6 mice.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 168.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.95 mL||29.73 mL||59.46 mL|
|5 mM||1.19 mL||5.95 mL||11.89 mL|
|10 mM||0.59 mL||2.97 mL||5.95 mL|
|50 mM||0.12 mL||0.59 mL||1.19 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Li et al (2012) Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice. Br.J.Pharmacol. 167 818 PMID: 22616721
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Keywords: LUF 6283, supplier, LUF6283, HCA2, hydroxycarboxylic, acid, receptors, GPR109A, HM74A, partial, agonists, Hydroxycarboxylic, Acid, Receptors, Hydroxycarboxylic, Acid, Receptors, Tocris Bioscience
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