LUF 6283

Discontinued Product

LUF 6283 (Cat. No. 4881) has been withdrawn from sale for commercial reasons.
Description: HCA2 (GPR109A) partial agonist
Chemical Name: 5-Butyl-1H-pyrazole-3-carboxylic acid
Purity: ≥98% (HPLC)

Biological Activity for LUF 6283

LUF 6283 is a partial agonist of hydroxycarboxylic acid receptor 2 (HCA2) (Ki = 0.55 μM). Thought to lower plasma very-low-density lipoprotein (VLDL)-triglyceride levels by affecting hepatic VLDL production in normolipidemic C57BL/6 mice.

Technical Data for LUF 6283

M. Wt 168.19
Formula C8H12N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 92933-48-7
PubChem ID 6485181
Smiles CCCCC1=CC(C(O)=O)=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for LUF 6283

References are publications that support the biological activity of the product.

Li et al (2012) Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice. Br.J.Pharmacol. 167 818 PMID: 22616721

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Keywords: LUF 6283, LUF 6283 supplier, LUF6283, HCA2, hydroxycarboxylic, acid, receptors, GPR109A, HM74A, partial, agonists, Hydroxycarboxylic, Acid, Receptors, 4881, Tocris Bioscience

Citations for LUF 6283

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Currently there are no citations for LUF 6283.

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