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Partial agonist of hydroxycarboxylic acid receptor 2 (HCA2) (Ki = 0.55 μM). Thought to lower plasma very-low-density lipoprotein (VLDL)-triglyceride levels by affecting hepatic VLDL production in normolipidemic C57BL/6 mice.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 168.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.95 mL||29.73 mL||59.46 mL|
|5 mM||1.19 mL||5.95 mL||11.89 mL|
|10 mM||0.59 mL||2.97 mL||5.95 mL|
|50 mM||0.12 mL||0.59 mL||1.19 mL|
References are publications that support the biological activity of the product.
Li et al (2012) Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice. Br.J.Pharmacol. 167 818 PMID: 22616721
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Keywords: LUF 6283, LUF 6283 supplier, LUF6283, HCA2, hydroxycarboxylic, acid, receptors, GPR109A, HM74A, partial, agonists, Hydroxycarboxylic, Acid, Receptors, 4881, Tocris Bioscience
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