LUF 6283

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Cat.No. 4881 - LUF 6283 | C8H12N2O2 | CAS No. 92933-48-7
Description: HCA2 (GPR109A) partial agonist
Chemical Name: 5-Butyl-1H-pyrazole-3-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Partial agonist of hydroxycarboxylic acid receptor 2 (HCA2) (Ki = 0.55 μM). Thought to lower plasma very-low-density lipoprotein (VLDL)-triglyceride levels by affecting hepatic VLDL production in normolipidemic C57BL/6 mice.

Technical Data

M. Wt 168.19
Formula C8H12N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 92933-48-7
PubChem ID 6485181
InChI Key ZJTXSGLJNBAMJS-UHFFFAOYSA-N
Smiles CCCCC1=CC(C(O)=O)=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.82 100
ethanol 16.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 168.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.95 mL 29.73 mL 59.46 mL
5 mM 1.19 mL 5.95 mL 11.89 mL
10 mM 0.59 mL 2.97 mL 5.95 mL
50 mM 0.12 mL 0.59 mL 1.19 mL

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References

References are publications that support the biological activity of the product.

Li et al (2012) Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice. Br.J.Pharmacol. 167 818 PMID: 22616721


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