LOC14

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Cat.No. 5606 - LOC14 | C16H19N3O2S | CAS No. 877963-94-5
Description: High affinity protein disulfide isomerase (PDI) modulator
Chemical Name: 2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity protein disulfide isomerase (PDI) modulator (Kd = 62 nM). Forces PDI to adopt an oxidized conformation and suppresses its activity. Neuroprotective.

Technical Data

M. Wt 317.41
Formula C16H19N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 877963-94-5
PubChem ID 9117962
InChI Key YVBSNHLFRIVWFQ-UHFFFAOYSA-N
Smiles O=C1C2=CC=CC=C2SN1CN3CCN(C(C4CC4)=O)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 317.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.75 mL 31.5 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Kaplan et al (2015) Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 112 E2245 PMID: 25848045


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Keywords: LOC14 High affinity protein disulfide isomerase PDI allosteric modulator Huntington disease Protein Disulfide Isomerase

Citations for LOC14

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Literature in this Area

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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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Cardiovascular Poster

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Gut Hormones

Gut Hormones Poster

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.

Pathways for LOC14

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