LMK 235

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Cat.No. 4830 - LMK 235 | C15H22N2O4 | CAS No. 1418033-25-6
Description: Selective HDAC4/HDAC5 inhibitor
Chemical Name: N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).

Compound Libraries

LMK 235 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 294.35
Formula C15H22N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1418033-25-6
PubChem ID 71520717
InChI Key VRYZCEONIWEUAV-UHFFFAOYSA-N
Smiles CC1=CC(C(NOCCCCCC(NO)=O)=O)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.43 100
ethanol 29.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 294.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.99 mL 33.97 mL
5 mM 0.68 mL 3.4 mL 6.79 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Marek et al (2013) Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J.Med.Chem. 56 427 PMID: 23252603


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View Related Products by Product Action

View all Class II HDAC Inhibitors

Keywords: LMK 235, LMK 235 supplier, LMK235, histone, deacetylases, HDAC, inhibitors, inhibits, chemoresistant, cancer, cytotoxicity, Class, II, HDACs, 4830, Tocris Bioscience

1 Citation for LMK 235

Citations are publications that use Tocris products. Selected citations for LMK 235 include:

Chen et al (2015) AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle 14 2520 PMID: 26061431


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Literature in this Area

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