LM 10

Pricing Availability   Qty
Cat.No. 5794 - LM 10 | C11H8FN5 | CAS No. 1316695-35-8
Description: Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
Chemical Name: 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Technical Data

M. Wt 229.21
Formula C11H8FN5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1316695-35-8
PubChem ID 91885138
InChI Key FSGAFWYMLAWNJM-UHFFFAOYSA-N
Smiles FC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 4.58 20 with gentle warming
DMSO 22.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 229.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.36 mL 21.81 mL 43.63 mL
5 mM 0.87 mL 4.36 mL 8.73 mL
10 mM 0.44 mL 2.18 mL 4.36 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

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References

References are publications that support the biological activity of the product.

Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID: 22308364

Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID: 21726069


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