Home / Pharmacology / Enzymes / Oxygenases/Oxidases / Tryptophan 2,3 dioxygenase / Tryptophan 2,3 dioxygenase Inhibitors / LM 10

LM 10

Cat. No. 5794 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
Chemical Name: 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for LM 10

LM 10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Technical Data for LM 10

M. Wt 229.21
Formula C11H8FN5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1316695-35-8
PubChem ID 91885138
InChI Key FSGAFWYMLAWNJM-UHFFFAOYSA-N
Smiles FC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LM 10

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.92 100
ethanol 4.58 20 with gentle warming

Preparing Stock Solutions for LM 10

The following data is based on the product molecular weight 229.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.36 mL 21.81 mL 43.63 mL
5 mM 0.87 mL 4.36 mL 8.73 mL
10 mM 0.44 mL 2.18 mL 4.36 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for LM 10

References are publications that support the biological activity of the product.

Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID: 22308364

Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID: 21726069

If you know of a relevant reference for LM 10, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Tryptophan 2,3 dioxygenase Inhibitors

Keywords: LM 10, LM 10 supplier, LM10, selective, 2,3-dioxygenase, TDO, inhibitors, inhibits, orally, bioavailable, anticancer, cancer, immunology, Tryptophan, 2,3, dioxygenase, Immune, Checkpoints, 5794, Tocris Bioscience

Citations for LM 10

Citations are publications that use Tocris products.

Currently there are no citations for LM 10. Do you know of a great paper that uses LM 10 from Tocris? Please let us know.

Reviews for LM 10

There are currently no reviews for this product. Be the first to review LM 10 and earn rewards!

Have you used LM 10?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Alzheimer's Poster

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.