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Description: Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
Chemical Name: 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
Purity: ≥98% (HPLC)
Biological Activity for LM 10
LM 10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.
Technical Data for LM 10
| M. Wt | 229.21 |
| Formula | C11H8FN5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1316695-35-8 |
| PubChem ID | 91885138 |
| InChI Key | FSGAFWYMLAWNJM-UHFFFAOYSA-N |
| Smiles | FC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LM 10
References for LM 10
References are publications that support the biological activity of the product.
Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID: 22308364
Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID: 21726069
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Keywords: LM 10, LM 10 supplier, LM10, selective, 2,3-dioxygenase, TDO, inhibitors, inhibits, orally, bioavailable, anticancer, cancer, immunology, Tryptophan, 2,3, dioxygenase, Immune, Checkpoints, 5794, Tocris Bioscience
Citations for LM 10
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Currently there are no citations for LM 10.
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