LM 10

Pricing Availability Delivery Time Qty
Cat.No. 5794 - LM 10 | C11H8FN5 | CAS No. 1316695-35-8
Description: Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
Chemical Name: 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Technical Data

M. Wt 229.21
Formula C11H8FN5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1316695-35-8
PubChem ID 91885138
InChI Key FSGAFWYMLAWNJM-UHFFFAOYSA-N
Smiles FC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.92 100
ethanol 4.58 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 229.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.36 mL 21.81 mL 43.63 mL
5 mM 0.87 mL 4.36 mL 8.73 mL
10 mM 0.44 mL 2.18 mL 4.36 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID: 2308364

Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID: 1726069


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