LM 10

Discontinued Product

LM 10 (Cat. No. 5794) has been withdrawn from sale for commercial reasons.
Description: Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
Chemical Name: 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for LM 10

LM 10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Technical Data for LM 10

M. Wt 229.21
Formula C11H8FN5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1316695-35-8
PubChem ID 91885138
InChI Key FSGAFWYMLAWNJM-UHFFFAOYSA-N
Smiles FC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for LM 10

References are publications that support the biological activity of the product.

Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID: 22308364

Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID: 21726069

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Citations for LM 10

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Currently there are no citations for LM 10.

Reviews for LM 10

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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