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Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 256.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.9 mL||19.51 mL||39.02 mL|
|5 mM||0.78 mL||3.9 mL||7.8 mL|
|10 mM||0.39 mL||1.95 mL||3.9 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
References are publications that support the biological activity of the product.
Yahara and Nishioka (1984) Flavonoid glucosides from licorice. Phytochemistry 23 2108
Mersereau et al (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol.Cell.Endocrinol. 283 49 PMID: 18177995
Kim et al (2008) Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production. Br.J.Pharmacol. 154 165 PMID: 18332856
If you know of a relevant reference for Liquiritigenin, please let us know.
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Keywords: Liquiritigenin, Liquiritigenin supplier, ERβ, ERb, ERbeta, selective, agonists, ERR, estrogen, receptors, anti-inflammatories, antiinflammatory, Estrogen, and, Related, Receptors, 3819, Tocris Bioscience
1 Citation for Liquiritigenin
Citations are publications that use Tocris products. Selected citations for Liquiritigenin include:
Gong et al (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12 e001 PMID: 25363786
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