Discontinued Product

Liquiritigenin (Cat. No. 3819) has been withdrawn from sale for commercial reasons.
Cat.No. 3819 - Liquiritigenin | C15H12O4 | CAS No. 578-86-9
Description: Selective ERβ agonist
Chemical Name: (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)
Pathways (1)

Biological Activity

Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.

Technical Data

M. Wt 256.25
Formula C15H12O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 578-86-9
PubChem ID 114829
Smiles OC(C=C3)=CC=[C@@]3[C@H](C2)OC1=CC(O)=CC=C1C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Yahara and Nishioka (1984) Flavonoid glucosides from licorice. Phytochemistry 23 2108

Mersereau et al (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol.Cell.Endocrinol. 283 49 PMID: 18177995

Kim et al (2008) Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production. Br.J.Pharmacol. 154 165 PMID: 18332856

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Keywords: Liquiritigenin, Liquiritigenin supplier, ERβ, ERb, ERbeta, selective, agonists, ERR, estrogen, receptors, anti-inflammatories, antiinflammatory, Estrogen, and, Related, Receptors, 3819, Tocris Bioscience

1 Citation for Liquiritigenin

Citations are publications that use Tocris products. Selected citations for Liquiritigenin include:

Gong et al (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12 e001 PMID: 25363786

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Literature in this Area

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Cancer Research Product Guide

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Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
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  • Retinoid X Receptors
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Pathways for Liquiritigenin


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.