Levetiracetam

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Cat.No. 2839 - Levetiracetam | C8H14N2O2 | CAS No. 102767-28-2
Description: Antiepileptic; binds SV2A
Alternative Names: Keppra, UCB L059
Chemical Name: (2S)-(2-Oxopyrrolidin-1-yl)butyramide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange.

Compound Libraries

Levetiracetam is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 170.21
Formula C8H14N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 102767-28-2
PubChem ID 5284583
InChI Key HPHUVLMMVZITSG-LURJTMIESA-N
Smiles O=C1N([C@@H](CC)C(N)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.02 100
water 17.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 170.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.88 mL 29.38 mL 58.75 mL
5 mM 1.18 mL 5.88 mL 11.75 mL
10 mM 0.59 mL 2.94 mL 5.88 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Smedt et al (2007) Levetiracetam: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13 43 PMID: 17461889

Ueda et al (2007) Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res. 1151 55 PMID: 17408599

Lynch et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proct.Natl.Acad.Sci. USA 101 9861 PMID:


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Citations for Levetiracetam

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