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Biological Activity for Levetiracetam
Levetiracetam is an antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange.
Compound Libraries for Levetiracetam
Technical Data for Levetiracetam
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Levetiracetam
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Levetiracetam
The following data is based on the product molecular weight 170.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.88 mL||29.38 mL||58.75 mL|
|5 mM||1.18 mL||5.88 mL||11.75 mL|
|10 mM||0.59 mL||2.94 mL||5.88 mL|
|50 mM||0.12 mL||0.59 mL||1.18 mL|
References for Levetiracetam
References are publications that support the biological activity of the product.
Smedt et al (2007) LeveT: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13 43 PMID: 17461889
Ueda et al (2007) Effect of LeveT on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res. 1151 55 PMID: 17408599
Lynch et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug LeveT. Proct.Natl.Acad.Sci. USA 101 9861 PMID: 15210974
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Keywords: Levetiracetam, Levetiracetam supplier, Anti-epileptic, binds, SV2A, Exocytosis, Endocytosis, Protein, Translocation, UCBL059, Keppra, UCB, L059, 2839, Tocris Bioscience
Citations for Levetiracetam
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