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Submit ReviewLevetiracetam
Description: Binds SV2A; antiepileptic
Alternative Names: Keppra, UCB L059
Chemical Name: (2S)-(2-Oxopyrrolidin-1-yl)butyramide
Purity: ≥99% (HPLC)
Biological Activity
Antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange.
Compound Libraries
Levetiracetam is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 170.21 |
| Formula | C8H14N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 102767-28-2 |
| PubChem ID | 5284583 |
| InChI Key | HPHUVLMMVZITSG-LURJTMIESA-N |
| Smiles | O=C1N([C@@H](CC)C(N)=O)CCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.02 | 100 | |
| DMSO | 17.02 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 170.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.88 mL | 29.38 mL | 58.75 mL |
| 5 mM | 1.18 mL | 5.88 mL | 11.75 mL |
| 10 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 50 mM | 0.12 mL | 0.59 mL | 1.18 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Smedt et al (2007) LeveT: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13 43 PMID: 17461889
Ueda et al (2007) Effect of LeveT on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res. 1151 55 PMID: 17408599
Lynch et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug LeveT. Proct.Natl.Acad.Sci. USA 101 9861
If you know of a relevant reference for Levetiracetam, please let us know.
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Keywords: Levetiracetam, Levetiracetam supplier, Anti-epileptic, binds, SV2A, Exocytosis, Endocytosis, Protein, Translocation, UCBL059, Keppra, UCB, L059, Translocation,, &, 2839, Tocris Bioscience
Citations for Levetiracetam
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Literature in this Area
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