Levetiracetam

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Cat.No. 2839 - Levetiracetam | C8H14N2O2 | CAS No. 102767-28-2
Description: Binds SV2A; antiepileptic
Alternative Names: Keppra, UCB L059
Chemical Name: (2S)-(2-Oxopyrrolidin-1-yl)butyramide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Levetiracetam

Levetiracetam is an antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange.

Compound Libraries for Levetiracetam

Levetiracetam is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Levetiracetam

M. Wt 170.21
Formula C8H14N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 102767-28-2
PubChem ID 5284583
InChI Key HPHUVLMMVZITSG-LURJTMIESA-N
Smiles O=C1N([C@@H](CC)C(N)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Levetiracetam

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.02 100
DMSO 17.02 100

Preparing Stock Solutions for Levetiracetam

The following data is based on the product molecular weight 170.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.88 mL 29.38 mL 58.75 mL
5 mM 1.18 mL 5.88 mL 11.75 mL
10 mM 0.59 mL 2.94 mL 5.88 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

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Product Datasheets for Levetiracetam

Certificate of Analysis / Product Datasheet
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References for Levetiracetam

References are publications that support the biological activity of the product.

Smedt et al (2007) LeveT: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13 43 PMID: 17461889

Ueda et al (2007) Effect of LeveT on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res. 1151 55 PMID: 17408599

Lynch et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug LeveT. Proct.Natl.Acad.Sci. USA 101 9861 PMID: 15210974


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Keywords: Levetiracetam, Levetiracetam supplier, Anti-epileptic, binds, SV2A, Exocytosis, Endocytosis, Protein, Translocation, UCBL059, Keppra, UCB, L059, 2839, Tocris Bioscience

Citations for Levetiracetam

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