Levetiracetam

Pricing Availability   Qty
Cat.No. 2839 - Levetiracetam | C8H14N2O2 | CAS No. 102767-28-2
Description: Binds SV2A; antiepileptic
Alternative Names: Keppra, UCB L059
Chemical Name: (2S)-(2-Oxopyrrolidin-1-yl)butyramide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange.

Compound Libraries

Levetiracetam is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 170.21
Formula C8H14N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 102767-28-2
PubChem ID 5284583
InChI Key HPHUVLMMVZITSG-LURJTMIESA-N
Smiles O=C1N([C@@H](CC)C(N)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.02 100
DMSO 17.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 170.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.88 mL 29.38 mL 58.75 mL
5 mM 1.18 mL 5.88 mL 11.75 mL
10 mM 0.59 mL 2.94 mL 5.88 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Smedt et al (2007) LeveT: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13 43 PMID: 17461889

Ueda et al (2007) Effect of LeveT on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res. 1151 55 PMID: 17408599

Lynch et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug LeveT. Proct.Natl.Acad.Sci. USA 101 9861


If you know of a relevant reference for Levetiracetam, please let us know.

View Related Products by Target

Keywords: Levetiracetam, Levetiracetam supplier, Anti-epileptic, binds, SV2A, Exocytosis, Endocytosis, Protein, Translocation, UCBL059, Keppra, UCB, L059, Translocation,, &, 2839, Tocris Bioscience

Citations for Levetiracetam

Citations are publications that use Tocris products.

Currently there are no citations for Levetiracetam. Do you know of a great paper that uses Levetiracetam from Tocris? Please let us know.

Reviews for Levetiracetam

There are currently no reviews for this product. Be the first to review Levetiracetam and earn rewards!

Have you used Levetiracetam?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells