Leuprolide

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Cat.No. 2873 - Leuprolide | Glp-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt | CAS No. 53714-56-0
Description: GnRH receptor agonist
Alternative Names: Leuoprorelin
Datasheet
Citations
Literature

Biological Activity

Gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, LHRH) receptor agonist. Suppresses estradiol, LH and FSH serum levels and represses the growth of experimental rat endometriosis.

Technical Data

M. Wt 1209.41
Formula C59H84N16O12
Sequence XHWSYLLRP

(Modifications: X1 = Glp, Pro-9 = Pro-NHEt)

Storage Desiccate at -20°C
CAS Number 53714-56-0
PubChem ID 90488782
InChI Key GFIJNRVAKGFPGQ-UILVTTEASA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.50 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1209.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.13 mL 8.27 mL
5 mM 0.17 mL 0.83 mL 1.65 mL
10 mM 0.08 mL 0.41 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Okada et al (1988) One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats. J.Pharmacol.Exp.Ther. 244 744 PMID: 3126294

Uday et al (2007) LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice. Eur.J.Pharmacol. 563 155 PMID: 17368614

Salvador et al (2001) Effects of the luteinising hormone-releasing hormone (LH-RH) agonist leuprolide on adenylyl cyclase regulation through G-protein coupled receptors in rat ventral prostate. Eur.J.Pharmacol. 37 641 PMID:


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Keywords: Leuprolide, supplier, GnRH, receptor, agonists, Receptors, Gonadotrophin-Releasing, Hormone, gonadotropin, chemotherapeutics, Leuoprorelin, Gonadotrophin-Releasing, Hormone, Receptors, Gonadotrophin-Releasing, Hormone, Receptors, Tocris Bioscience

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