Potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT1 and BLT2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50µg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.86 mL||29.72 mL|
|5 mM||0.59 mL||2.97 mL||5.94 mL|
|10 mM||0.3 mL||1.49 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References are publications that support the products' biological activity.
Bray et al (1981) Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins 22 213 PMID: 6270742
Ford-Hutchinson (1990) Leukotriene B4 in inflammation. Crit.Rev.Immunol. 10 1 PMID: 2155000
Yokomitso et al (2001) Leukotriene B4: metabolism and signal transduction. Arch.Biochem.Biophys. 385 231 PMID: 11368003
If you know of a relevant reference for Leukotriene B4, please let us know.
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