Leukotriene B4

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Cat.No. 2307 - Leukotriene B4 | C20H32O4 | CAS No. 71160-24-2
Description: BLT1/BLT2 receptor agonist and potent chemotactic factor
Alternative Names: LTB4, 5,12-DiHETE
Chemical Name: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT1 and BLT2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.

Technical Data

M. Wt 336.47
Formula C20H32O4
Storage Store at -20°C
CAS Number 71160-24-2
PubChem ID 5280492
InChI Key VNYSSYRCGWBHLG-AMOLWHMGSA-N
Smiles O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50µg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.72 mL
5 mM 0.59 mL 2.97 mL 5.94 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Bray et al (1981) Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins 22 213 PMID: 6270742

Ford-Hutchinson (1990) Leukotriene B4 in inflammation. Crit.Rev.Immunol. 10 1 PMID: 2155000

Yokomitso et al (2001) Leukotriene B4: metabolism and signal transduction. Arch.Biochem.Biophys. 385 231 PMID: 11368003


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Keywords: Leukotriene B4, Leukotriene B4 supplier, BLT1, BLT2, receptor, agonists, potent, Receptors, leukotrienes, eicosanoids, LeukotrieneB4, LTB4, 5,12-DiHETE, Leukotriene, and, Related, Antivirals, 2307, Tocris Bioscience

1 Citation for Leukotriene B4

Citations are publications that use Tocris products. Selected citations for Leukotriene B4 include:

Fernandes et al (2013) Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. FASEB J 27 1664 PMID: 23271050


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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