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Submit ReviewLeukotriene B4
Description: BLT1/BLT2 receptor agonist and potent chemotactic factor
Alternative Names: LTB4, 5,12-DiHETE
Chemical Name: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
Purity: ≥97% (HPLC)
Biological Activity for Leukotriene B4
Leukotriene B4 is a potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT1 and BLT2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.
Technical Data for Leukotriene B4
| M. Wt | 336.47 |
| Formula | C20H32O4 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 71160-24-2 |
| PubChem ID | 5280492 |
| InChI Key | VNYSSYRCGWBHLG-AMOLWHMGSA-N |
| Smiles | O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Leukotriene B4
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50µg/ml) |
Product Datasheets for Leukotriene B4
References for Leukotriene B4
References are publications that support the biological activity of the product.
Bray et al (1981) Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins 22 213 PMID: 6270742
Ford-Hutchinson (1990) Leukotriene B4 in inflammation. Crit.Rev.Immunol. 10 1 PMID: 2155000
Yokomitso et al (2001) Leukotriene B4: metabolism and signal transduction. Arch.Biochem.Biophys. 385 231 PMID: 11368003
If you know of a relevant reference for Leukotriene B4, please let us know.
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1 Citation for Leukotriene B4
Citations are publications that use Tocris products. Selected citations for Leukotriene B4 include:
Fernandes et al (2013) Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. FASEB J 27 1664 PMID: 23271050
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