Leukotriene B4

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Cat.No. 2307 - Leukotriene B4 | C20H32O4 | CAS No. 71160-24-2
Description: BLT1/BLT2 receptor agonist and potent chemotactic factor
Alternative Names: LTB4, 5,12-DiHETE
Chemical Name: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
Datasheet
Citations
Literature

Biological Activity

Potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT1 and BLT2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.

Technical Data

M. Wt 336.47
Formula C20H32O4
Storage Store at -20°C
CAS Number 71160-24-2
PubChem ID 5280492
InChI Key VNYSSYRCGWBHLG-AMOLWHMGSA-N
Smiles O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50µg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.72 mL
5 mM 0.59 mL 2.97 mL 5.94 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bray et al (1981) Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins 22 213 PMID: 6270742

Ford-Hutchinson (1990) Leukotriene B4 in inflammation. Crit.Rev.Immunol. 10 1 PMID: 2155000

Yokomitso et al (2001) Leukotriene B4: metabolism and signal transduction. Arch.Biochem.Biophys. 385 231 PMID: 11368003


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Citations for Leukotriene B4

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