Leptomycin B

Discontinued Product

Leptomycin B (Cat. No. 1987) has been withdrawn from sale for commercial reasons.
Description: Inhibits nuclear export of proteins; antitumor
Alternative Names: CI 940,LMB
Chemical Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Citations (4)

Biological Activity for Leptomycin B

Leptomycin B is an antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo.

Technical Data for Leptomycin B

M. Wt 540.74
Formula C33H48O6
Storage Desiccate at -20°C
CAS Number 87081-35-4
PubChem ID 57459335
Smiles CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C/[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Leptomycin B

Certificate of Analysis / Product Datasheet
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References for Leptomycin B

References are publications that support the biological activity of the product.

Roberts et al (1986) In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI 940 and its hydroxy analog (PD 114,721). Cancer Chemother.Pharmacol. 16 95 PMID: 3081269

Wolff et al (1997) Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem.Biol. 4 139 PMID: 9190288

Freedman and Levine (1998) Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol.Cell.Biol. 18 7288 PMID: 9819415

Kudo et al (1998) Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp.Cell Res. 242 540 PMID: 9683540

Keywords: Leptomycin B, Leptomycin B supplier, inhibitors, inhibits, nuclear, export, proteins, antitumor, Protein, Translocation, LeptomycinB, CI940, antibiotics, CI, 940, LMB, Antibiotics, Antifungals, 1987, Tocris Bioscience

4 Citations for Leptomycin B

Citations are publications that use Tocris products. Selected citations for Leptomycin B include:

Horan et al (2013) Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol 190 2311 PMID: 23345332

Cao et al (2014) Characterization of the nucleocytoplasmic shuttle of the matrix protein of influenza B virus. J Virol 88 7464 PMID: 24741102

Zheng et al (2019) Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export. Cell Rep 27 1875 PMID: 31067470

Cao et al (2012) A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication. J Virol 86 4883 PMID: 22345442

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