Home / Cell Biology / Signal Transduction / Translocation, Exocytosis & Endocytosis / Leptomycin B

Leptomycin B

Cat. No. 1987 3 Citations COA / Product Datasheet SDS
Pricing Availability Delivery Time Qty
Cat.No. 1987 - Leptomycin B | C33H48O6 | CAS No. 87081-35-4
Description: Inhibits nuclear export of proteins; antitumor
Alternative Names: CI 940, LMB
Chemical Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Datasheet
Citations (3)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo.

Technical Data

M. Wt 540.74
Formula C33H48O6
Storage Desiccate at -20°C
CAS Number 87081-35-4
PubChem ID 57459335
InChI Key YACHGFWEQXFSBS-RJXCBBHPSA-N
Smiles CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C/[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 27µg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 540.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Roberts et al (1986) In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI 940 and its hydroxy analog (PD 114,721). Cancer Chemother.Pharmacol. 16 95 PMID: 3081269

Wolff et al (1997) Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem.Biol. 4 139 PMID: 9190288

Freedman and Levine (1998) Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol.Cell.Biol. 18 7288 PMID: 9819415

Kudo et al (1998) Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp.Cell Res. 242 540 PMID: 9683540

If you know of a relevant reference for Leptomycin B, please let us know.

View Related Products by Target

Keywords: Leptomycin B, supplier, inhibitors, inhibits, nuclear, export, proteins, antitumor, Protein, Translocation, LeptomycinB, CI940, antibiotics, CI, 940, LMB, Translocation,, Exocytosis, &, Endocytosis, Antibiotics, Translocation,, Exocytosis, &, Endocytosis, Tocris Bioscience

3 Citations for Leptomycin B

Citations are publications that use Tocris products. Selected citations for Leptomycin B include:

Cao et al (2014) Characterization of the nucleocytoplasmic shuttle of the matrix protein of influenza B virus. J Virol 88 7464 PMID: 24741102

Cao et al (2012) A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication. J Virol 86 4883 PMID: 22345442

Horan et al (2013) Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol 190 2311 PMID: 23345332

Do you know of a great paper that uses Leptomycin B from Tocris? If so please let us know.

Reviews for Leptomycin B

There are currently no reviews for this product. Be the first to review Leptomycin B and earn rewards!

Have you used Leptomycin B?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis